Results 41 to 50 of about 620,119 (261)

The macrophage scavenger receptor at 30 years of age: current knowledge and future challenges

Journal of Lipid Research, 2009
It is now thirty years since the original observation that macrophages take up and degrade modified forms of low density lipoprotein (LDL). Molecular cloning has identified multiple scavenger receptors that can endocytose modified LDL and binding studies
David R. Greaves, Siamon Gordon
doaj   +1 more source

Lipoprotein receptor interactions are not required for monocyte oxidation of LDL.

Journal of Lipid Research, 1995
Upon activation, human peripheral blood monocytes and U937 cells oxidized low density lipoprotein (LDL), converting it to a cytotoxin. The oxidized LDL loses its ability to interact specifically with the native LDL (apoB/E) receptor and becomes a ligand ...
M K Cathcart, Q Li, G M Chisolm, 3rd
doaj   +1 more source

Class A scavenger receptor 1 (MSR1) restricts hepatitis C virus replication by mediating toll-like receptor 3 recognition of viral RNAs produced in neighboring cells [PDF]

, 2013
Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health.
McGivern, David R., Fengyu Hu, Daisuke Yamane (206804), David R McGivern, Hu, Fengyu, Hiromichi Dansako (357935), Nobuyuki Kato (235685), Christoph Welsch (22852), Stanley M. Lemon (30543), Daisuke Yamane, Christoph Welsch, Welsch, Christoph, David R. McGivern (415119), Lemon, Stanley M., Kato, Nobuyuki, Fengyu Hu (415120), Dansako, Hiromichi, Stanley M Lemon, Yamane, Daisuke, Nobuyuki Kato, Hiromichi Dansako   +20 more
core   +1 more source

Scavenger receptors in human airway epithelial cells: role in response to double-stranded RNA.

PLoS ONE, 2012
Scavenger receptors and Toll-like receptors (TLRs) cooperate in response to danger signals to adjust the host immune response. The TLR3 agonist double stranded (ds)RNA is an efficient activator of innate signalling in bronchial epithelial cells.
Audrey Dieudonné, David Torres, Simon Blanchard, Solenne Taront, Pascale Jeannin, Yves Delneste, Muriel Pichavant, François Trottein, Philippe Gosset   +8 more
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Protective or deleterious role of scavenger receptors SR-A and CD36 on host resistance to Staphylococcus aureus depends on the site of infection. [PDF]

PLoS ONE, 2014
Staphylococcus aureus is a major human opportunistic pathogen responsible for a broad spectrum of infections ranging from benign skin infection to more severe life threatening disorders (e.g.
Charlène Blanchet, Gregory Jouvion, Catherine Fitting, Jean-Marc Cavaillon, Minou Adib-Conquy   +4 more
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Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors

Journal of Lipid Research, 1993
Macrophage scavenger receptors have been implicated in various macrophage-associated processes, including atherosclerosis and clearance of bacterial endotoxin. They bind to a wide variety of polyanionic ligands and display complex binding characteristics.
J Ashkenas, M Penman, E Vasile, S Acton, M Freeman, M Krieger   +5 more
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CXCR7 functions as a scavenger for CXCL12 and CXCL11. [PDF]

, 2010
CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is
Pruenster, M, Mahabaleshwar, Harsha, Ulrike Naumann, Raz Erez, Rot, Antal, Rot Antal, Marcus Thelen, Naumann, U, Zerwes Hans-Günter, Harsha Mahabaleshwar, Naumann Ulrike, Cameroni, E, Mahabaleshwar, H, Elisabetta Cameroni, Zerwes, Hans-Günter, Raz, E, Pruenster Monika, Mahabaleshwar Harsha, Monika Pruenster, Hans-Günter Zerwes, Pruenster, Monika, Thelen, M, Thelen Marcus, Naumann, Ulrike, Cameroni, Elisabetta, Cameroni Elisabetta, Raz, Erez, Zerwes, HG, Antal Rot, Erez Raz, Thelen, Marcus   +30 more
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Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages.

Journal of Lipid Research, 1981
Improved techniques of cell isolation resulted in 90 to 100 million monocytes from a single donor. Addition of low density lipoprotein (LDL) to to cultures of these cells resulted in the down regulation of LDL receptor activity.
A M Fogelman, M E Haberland, J Seager, M Hokom, P A Edwards   +4 more
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Hydroxychloroquine Effects on THP-1 Macrophage Cholesterol Handling: Cell Culture Studies Corresponding to the TARGET Cardiovascular Trial

Medicina, 2022
Background and Objectives: Cardiovascular (CV) risk is elevated in rheumatoid arthritis (RA). RA patient plasma causes pro-atherogenic derangements in cholesterol transport leading to macrophage foam cell formation (FCF).
Saba Ahmed, Justin Konig, Lora J. Kasselman, Heather A. Renna, Joshua De Leon, Steven E. Carsons, Allison B. Reiss   +6 more
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Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection

Nature Communications, 2017
Scavenger receptors can function as pattern recognition receptors to sense infection. Here the authors show that, in response to worm and bacterial infection, scavenger receptor class A prevents nuclear localization of IRF5 and thereby drives M2 ...
Zhipeng Xu, Lei Xu, Wei Li, Xin Jin, Xian Song, Xiaojun Chen, Jifeng Zhu, Sha Zhou, Yong Li, Weiwei Zhang, Xiaoxiao Dong, Xiaowei Yang, Feng Liu, Hui Bai, Qi Chen, Chuan Su   +15 more
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