Results 71 to 80 of about 63,687 (336)

Exogenous Short Chain Fatty Acid Effects in APP/PS1 Mice

Frontiers in Neuroscience, 2022
Elucidating the impact of the gut microbiome on Alzheimer’s Disease (AD) is an area of intense interest. Short chain fatty acids (SCFAs) are major microbiota metabolites that have been implicated as a mediator of gut microbiome effects in the brain. Here,
Diana J. Zajac, Benjamin C. Shaw, David J. Braun, Stefan J. Green, Joshua M. Morganti, Steven Estus   +5 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Gastric infusion of short-chain fatty acids can improve intestinal barrier function in weaned piglets

Genes & Nutrition, 2019
Background The present study was conducted to investigate the effects of gastric infusion of short-chain fatty acids (SCFA) on gut barrier function in a pig model. In this study, 21 DLY barrows with an average initial body weight of (8.31 ± 0.72) kg were
H. Diao, A. R. Jiao, B. Yu, X. B. Mao, D. W. Chen   +4 more
doaj   +1 more source

The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats

Journal of Nutrition and Metabolism, 2023
Liver damage characterized by fibrosis and necrosis can worsen the condition of liver disease. Liver disease is associated with impaired immune response and may affect short-chain fatty acid (SCFA) gut metabolites.
Hery D. Purnomo, Refani A. Kusuma, Elfrida Sianturi, Ryan F. Haroen, Muchamad R. Solichin, Choirun Nissa, Adriyan Pramono, Endang Mahati, Etika R. Noer   +8 more
doaj   +1 more source

Fecal levels of SCFA and BCFA during capecitabine in patients with metastatic or unresectable colorectal cancer

, 2023
BackgroundGut bacteria-derived short-chain fatty acids (SCFA) and branched-chain fatty acids (BCFA) are considered to have beneficial metabolic, anti-inflammatory as well as anti-carcinogenic effects.
de Vos-Geelen, J., Baars, A., Ziemons, J., Waelen, J., Penders, J., Vestjens, J.H.M.J., Aarnoutse, R., Iersel, L.V.V., Heuft, A., Hillege, L., van Hellemond, I.E.G., Smidt, M.L., Ziemons, J.; id_orcid, Creemers, G.J.M., Venema, K.   +14 more
core   +1 more source

SCFAs alleviated steatosis and inflammation in mice with NASH induced by MCD [PDF]

Journal of Endocrinology, 2020
This study aimed to assess the effects of three major SCFAs (acetate, propionate, and butyrate) on NASH phenotype in mice. C57BL/6 mice were fed a methionine- and choline-deficient (MCD) diet and treated with sodium acetate, sodium propionate, or sodium butyrate during the 6-week feeding period.
Mingjuan, Deng, Fang, Qu, Long, Chen, Chang, Liu, Ming, Zhang, Fazheng, Ren, Huiyuan, Guo, Hao, Zhang, Shaoyang, Ge, Chaodong, Wu, Liang, Zhao   +10 more
openaire   +2 more sources

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways.

Cell Reports, 2016
The incidence of food allergies in western countries has increased dramatically in recent decades. Tolerance to food antigens relies on mucosal CD103(+) dendritic cells (DCs), which promote differentiation of regulatory T (Treg) cells.
Jian Tan, Craig I. McKenzie, P. Vuillermin, G. Goverse, C. Vinuesa, R. Mebius, L. Macia, C. Mackay   +7 more
semanticscholar   +1 more source

Night-time feeding of Bmal1-/- mice restores SCFA rhythms and their effect on ghrelin.

Journal of Endocrinology, 2020
The known crosstalk between short-chain fatty acids (SCFAs) and the circadian clock is tightly intertwined with feeding time. We aimed to investigate the role of the core clock gene Bmal1 and feeding time in the diurnal rhythms in plasma and caecal SCFAs
Anneleen Segers, L. Desmet, Shuran Sun, K. Verbeke, J. Tack, I. Depoortere   +5 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Relationship of SCFAs to Maternal and Child Anthropometric Measurements

International Journal of Molecular Sciences
Short-chain fatty acids (SCFAs) are involved in metabolism and physiological processes. We decided to investigate whether SCFAs are engaged in the metabolic programming of the offspring by the mother’s microbiota, which interact during pregnancy, delivery, and breastfeeding.
Małgorzata Szczuko, Natalia Szabunia, Julia Radkiewicz, Dominika Jamioł-Milc, Tomasz Machałowski, Maciej Ziętek   +5 more
openaire   +2 more sources