Results 101 to 110 of about 747,950 (326)

Production Scheduling of Multi-Stage, Multi-product Food Process Industries

, 2018
The production scheduling of a real-life multi-product, mixed batch and continuous food industrial facility is considered in this work. More specifically, the scheduling of canned fish production in a large-scale Spanish industry is studied in detail. The deployment of an efficient solution strategy is proposed to handle the computationally challenging
Georgiadis, Georgios P., Ziogou, Chrysovalantou, Kopanos, Georgios, Garcia, Manuel, Cabo, Daniel, Lopez, Miguel, Georgiadis, Michael C.   +6 more
openaire   +2 more sources

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

FEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten, Lorenz Schwaiger, Zarah Forsberg, Kelsi R. Hall, Anton A. Stepnov, Tom Z. Emrich‐Mills, Iván Ayuso‐Fernández, Morten Sørlie, Roland Ludwig, Åsmund Kjendseth Røhr, Vincent G. H. Eijsink   +10 more
wiley   +1 more source

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

FEBS Letters, EarlyView.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin, Danielle M. Colussi, Peter B. Stathopulos   +2 more
wiley   +1 more source

Production Scheduling Based on a Multi-Agent System and Digital Twin: A Bicycle Industry Case

Information
The emerging digitalization in today’s industrial environments allows manufacturers to store online knowledge about production and use it to make better informed management decisions. This paper proposes a multi-agent framework enhanced with digital twin
Vasilis Siatras, Emmanouil Bakopoulos, Panagiotis Mavrothalassitis, Nikolaos Nikolakis, Kosmas Alexopoulos   +4 more
doaj   +1 more source

Co-evolutionary Genetic Algorithms for Reactive Scheduling

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2010
Previous researches provided a reactive scheduling method using a genetic algorithm to improve disturbed production schedules, due to unexpected disruptions, such as delays of manufacturing operations.
Yoshitaka TANIMIZU, Yusuke KOMATSU, Chisato OZAWA, Koji IWAMURA, Nobuhiro SUGIMURA   +4 more
doaj   +1 more source

Efficient scheduling using complex networks [PDF]

arXiv, 2012
We consider the problem of efficiently scheduling the production of goods for a model steel manufacturing company. We propose a new approach for solving this classic problem, using techniques from the statistical physics of complex networks in conjunction with depth-first search to generate a successful, flexible, schedule.
arxiv  

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, EarlyView.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Guidelines for the deployment and implementation of manufacturing scheduling systems [PDF]

, 2011
It has frequently been stated that there exists a gap between production scheduling theory and practice. In order to put theoretical findings into practice, advances in scheduling models and solution procedures should be embedded into a piece of software
Cowling P, Crawford S, Ford FN, Grant TJ, Jose M. Framinan, Knolmayer G, Laforge RL, Ledbetter WN, MacCarthy B, McKay KN, Meador CL, Pinedo ML, Prietula MJ, Rubén Ruiz, Sauer J, Vernon C, Webster S, Wiers VCS   +17 more
core   +2 more sources

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

ÖĞRENME ETKİLİ HAZIRLIK VE TAŞIMA ZAMANLI PARALEL MAKİNELİ ÇİZELGELEME PROBLEMİ

Havacılık ve Uzay Teknolojileri Dergisi, 2006
In studies on scheduling problems, generally setup times and removal times of jobs have been neglected or by including those into processing times solution approaches have been developed.
Tamer Eren , Ertan Güner
doaj