Results 101 to 110 of about 775,681 (328)
FEBS Letters, Volume 599, Issue 8, Page 1159-1168, April 2025.In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri +8 more
wiley +1 more source
A simulation engine to support production scheduling using genetics-based machine learning [PDF]
In: K. Mertins, O. Krause, and B. Schallock (eds), Global
Production Management, pp. 482-489. 1999, Kluwer Academic Publishers, 2006 The ever higher complexity of manufacturing systems, continually shortening life cycles of products and their increasing variety, as well as the unstable market situation of the recent years require introducing grater flexibility and responsiveness to manufacturing processes.
arxiv
Response of Fresh Food Suppliers to Sustainable Supply Chain Management of Large European Retailers [PDF]
, 2019 This article analyses new supply chain management (SCM) strategies of the largest retail distribution chains in Europe within the context of differing sustainability concepts and approaches.
Badole +22 more
core +2 more sources
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
FEBS Letters, Volume 599, Issue 9, Page 1317-1336, May 2025.This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten +10 more
wiley +1 more source
FEBS Letters, Volume 599, Issue 7, Page 971-988, April 2025.We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin +2 more
wiley +1 more source
ÖĞRENME ETKİLİ HAZIRLIK VE TAŞIMA ZAMANLI PARALEL MAKİNELİ ÇİZELGELEME PROBLEMİ
Havacılık ve Uzay Teknolojileri Dergisi, 2006 In studies on scheduling problems, generally setup times and removal times of jobs have been neglected or by including those into processing times solution approaches have been developed.
Tamer Eren , Ertan Güner
doaj
Planning, Scheduling, and Uncertainty in the Sequence of Future Events [PDF]
arXiv, 2013 Scheduling in the factory setting is compounded by computational complexity and temporal uncertainty. Together, these two factors guarantee that the process of constructing an optimal schedule will be costly and the chances of executing that schedule will be slight.
arxiv
Immunoregulatory mechanisms of the arachidonic acid pathway in cancer
FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine +3 more
wiley +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Multiobjective Lot Sizing and Scheduling of Multiproduct Switching Production in the Process Industry Considering Uncertain Market Information Under Mass Customization [PDF]
, 2022 Qi Tang, Yiran Wang
openalex +1 more source