Results 71 to 80 of about 270,524 (304)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Forensic Schema Therapy: Theoretical Foundations

Психология и право
The article discusses the theoretical model of schema therapy and provides an overview of research on its adaptation for individuals with convictions and those who have committed criminal acts under the influence of a mental illness.
E.D. Surgutskiy, G.A. Vartanyan
doaj   +1 more source

Dangerous ontologies: the ethos of survival and ethical theorising in international relations [PDF]

, 2002
The article responds to a recent call for a more systematic interrogation of the persistence of the dichotomous relation between ethics and International Relations.
Odysseos, Louiza
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The Effectiveness of Emotional Schema Therapy on Neuroticism and the Life Style of Cardiovascular Patients

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2021
BACKGROUND AND OBJECTIVE: Neuroticism and extroversion have a high and positive relationship with psychological problems such as anxiety and depression.
Z Khodadad Hatkeh Poshti, R Hassanzadeh, SO Emadian   +2 more
doaj  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Rehabilitative devices for a top-down approach [PDF]

, 2019
In recent years, neurorehabilitation has moved from a "bottom-up" to a "top down" approach. This change has also involved the technological devices developed for motor and cognitive rehabilitation.
de Bartolo, Daniela, Di Iulio, Fulvia, Ghanbari Ghooshchy, Sheida, Iosa, Marco, Morone, Giovanni, Paolucci, Stefano, Spitoni, Grazia Fernanda, Zoccolotti, Pierluigi   +7 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Comparing efficacy of schema therapy & emotion-oriented therapy on adherence to treatment in patients with MS [PDF]

مجله علوم روانشناختی
Background: Low treatment adherence in patients with MS leads to poor treatment outcomes and higher care costs. Studies have reported on the effect of schema therapy to improvement adherence to treatment, also, emotion-oriented therapy by empowering ...
Azita Mohaghegh, Biuok Tajeri, hadi keramati   +2 more
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source