Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Forensic Schema Therapy: Theoretical Foundations
Психология и правоThe article discusses the theoretical model of schema therapy and provides an overview of research on its adaptation for individuals with convictions and those who have committed criminal acts under the influence of a mental illness.
E.D. Surgutskiy, G.A. Vartanyan
doaj +1 more source
The Minds of Black Women — Impacts on Mental Health and Well-Being Across Collective Identities and Experience [PDF]
, 2020 Limited research investigates how structural and institutional barriers affect Black women's mental health. Further, stereotypes and tropes such as the Angry Black Woman and Strong Black Woman are impactful. Black women's proximity to wellness is largely
Campbell, Kayla
core
Kinaesthetic Intersubjectivity: : A dance informed contribution to self-other relatedness and shared experience in nonverbal psychotherapy with an example from Autism [PDF]
, 2012 This document is the Accepted Manuscript version of the following article: Rosemarie Samaritter and Helen Payne, ‘Kinaesthetic intersubjectivity: A dance informed contribution to self-other relatedness and shared experience in non-verbal psychotherapy ...
Payne, Helen, Samaritter, Rosemarie
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2021 BACKGROUND AND OBJECTIVE: Neuroticism and extroversion have a high and positive relationship with psychological problems such as anxiety and depression.
Z Khodadad Hatkeh Poshti +2 more
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Comparing efficacy of schema therapy & emotion-oriented therapy on adherence to treatment in patients with MS [PDF]
مجله علوم روانشناختیBackground: Low treatment adherence in patients with MS leads to poor treatment outcomes and higher care costs. Studies have reported on the effect of schema therapy to improvement adherence to treatment, also, emotion-oriented therapy by empowering ...
Azita Mohaghegh +2 more
doaj
The Effectiveness of Emotional Schema Therapy on Cognitive Emotion Regulation, Intolerance of Uncertainty and Cognitive Flexibility in People with Generalized Anxiety Disorder [PDF]
Ravānshināsī-i Afrād-i Istis̠nāyīThe aim of this study was to evaluate the effectiveness of emotional schema therapy on cognitive emotion regulation, intolerance of uncertainty and cognitive flexibility in people with generalized anxiety disorder.
Kobra Ghanizadeh Balderloo +3 more
doaj +1 more source