IL-33/ST2 Axis Deficiency Exacerbates Hepatic Pathology by Regulating Treg and Th17 Cells in Murine Schistosomiasis Japonica. [PDF]
Purpose Schistosoma japonicum-infected IL-33 and ST2 gene deficiency (IL-33−/− and ST2−/−, respectively) mice were used to explore the role of the IL-33/ST2 axis in liver pathology targeting regulatory T cells (Treg)/T helper 17 cells (Th17).
Bai Y+7 more
europepmc +2 more sources
Whole-Proteome Differential Screening Identifies Novel Vaccine Candidates for Schistosomiasis japonica. [PDF]
Schistosomiasis remains a leading cause of chronic morbidity in endemic regions despite decades of widespread mass chemotherapy with praziquantel.
Wu HW+11 more
europepmc +2 more sources
Single-cell RNA sequencing reveals a peripheral landscape of immune cells in Schistosomiasis japonica [PDF]
Background Schistosomiasis, also known as bilharzia, is a devastating parasitic disease. This progressive and debilitating helminth disease is often associated with poverty and can lead to chronic poor health. Despite ongoing research, there is currently
Junhui Li+8 more
doaj +2 more sources
Schistosomiasis Japonica Control in Domestic Animals: Progress and Experiences in China [PDF]
Schistosomiasis japonica, caused by Schistosoma japonicum, is an endemic, zoonotic parasitic disease. Domestic animals, particularly bovines, are thought to play an important role in transmission of the disease. Historically, China was the country mostly
Zhiguo Cao+3 more
doaj +2 more sources
Evaluation of a real-time PCR assay for diagnosis of schistosomiasis japonica in the domestic goat. [PDF]
Background Schistosomiasis japonica is an infectious disease caused by Schistosoma japonicum that seriously endangers human health. Domestic animals have important roles in disease transmission and goats are considered a primary reservoir host and source
Guo Q+12 more
europepmc +2 more sources
Hepatocyte CD1d protects against liver immunopathology in mice with schistosomiasis japonica [PDF]
Schistosomiasis is a neglected tropical disease with over 250 million people infected worldwide. The main clinically important species Schistosoma mansoni (S. mansoni) and Schistosoma japonicum (S.
Zhigang Lei+16 more
openalex +2 more sources
Case Report: Multiple Schistosomiasis Japonica Cerebral Granulomas without Gastrointestinal System Involvement: Report of Two Cases and Review of Literature. [PDF]
Most schistosomiasis japonica cerebral granulomas reported in the literature have been single and located in the cerebellum, and multiple lesions located in the cerebral hemisphere are uncommon and often misdiagnosed as metastases or gliomas. We describe
Shen J, Yuan L, Sun Y, Jiang X, Shao X.
europepmc +2 more sources
Therapeutic potential of fucoidan in the reduction of hepatic pathology in murine schistosomiasis japonica. [PDF]
Background Hepatic granuloma formation and fibrosis as the consequence of tissue entrapped eggs produced by female schistosomes characterize the pathology of Schistosoma japonicum infection.
Bai X+12 more
europepmc +2 more sources
Detection of Schistosoma japonicum and Oncomelania hupensis quadrasi environmental DNA and its potential utility to schistosomiasis japonica surveillance in the Philippines. [PDF]
In recent years, the prevalence and infection intensity of Schistosoma japonicum in endemic areas of the Philippines have significantly decreased due to yearly population-based treatment strategies, yet transmission rates remain high and uninterrupted ...
Fornillos RJC+9 more
europepmc +2 more sources
A Parallel Comparison of Antigen Candidates for Development of an Optimized Serological Diagnosis of Schistosomiasis Japonica in the Philippines [PDF]
Schistosoma japonicum is stubbornly persistent in China and the Philippines. Fast and accurate diagnostic tools are required to monitor effective control measures against schistosomiasis japonica.
Pengfei Cai+9 more
doaj +2 more sources