Results 51 to 60 of about 1,542 (158)

An association of Aquaporin-4 with the immunoregulation of liver pathology in mice infected with Schistosoma japonicum

Parasites & Vectors, 2015
Background Schistosomiasis is a chronic parasitic disease that affects approximately 200 million people. In Schistosomiasis japonica and mansoni, parasite eggs were trapped in host liver and stimulated the CD4+T cell responses to regulate the formation ...
Weiwei Zhang, Jifeng Zhu, Xian Song, Zhipeng Xu, Xue Xue, Xiaojun Chen, Xiaowei Yang, Yong Li, Xiaoxiao Dong, Sha Zhou, Wei Li, Yingying Qian, Feng Liu, Chuan Su   +13 more
doaj   +1 more source

Real-time observation of pathophysiological processes during murine experimental Schistosoma japonicum infection using high-resolution ultrasound imaging

Tropical Medicine and Health, 2018
Background Hepatosplenic lesion formation is one of the typical clinical symptoms of schistosomiasis japonica. Although it is established that circum-oval granuloma formation mediated by T lymphocytes is the key event triggering the formation of hepatic ...
Katsumi Maezawa, Rieko Furushima-Shimogawara, Akio Yasukawa, Nobuo Ohta, Shiro Iwanaga   +4 more
doaj   +1 more source

Characteristics of Intestinal Flora in Patients With Schistosoma japonicum Infection Undergoing Splenectomy

Parasite Immunology, Volume 47, Issue 5, May 2025.
ABSTRACT Schistosomiasis japonica is a parasitic disease that seriously endangers human health. Patients with advanced Schistosoma japonicum infection often suffer from cirrhosis and portal hypertension. Splenectomy has been widely used in the treatment of these patients. Previous studies have confirmed that S. japonicum infection is closely related to
Chen Zhou, Pengpeng Zhang, Yingzi Ming
wiley   +1 more source

Gut Microbiota Modulates Intestinal Pathological Injury in Schistosoma japonicum-Infected Mice

Frontiers in Medicine, 2020
Trapping of Schistosoma japonicum (S. japonicum) eggs in host tissue, mainly in the intestine and liver, causes severe gastrointestinal and hepatic granulomatous immune responses and irreversible fibrosis. Although the gut microbiota plays a central role
Beibei Zhang, Beibei Zhang, Beibei Zhang, Beibei Zhang, Beibei Zhang, Xiaoying Wu, Qiuyue Song, Qiuyue Song, Qiuyue Song, An Ning, Jinyi Liang, Jinyi Liang, Jinyi Liang, Langui Song, Langui Song, Langui Song, Jiahua Liu, Jiahua Liu, Jiahua Liu, Yishu Zhang, Dongjuan Yuan, Xi Sun, Xi Sun, Xi Sun, Zhongdao Wu, Zhongdao Wu, Zhongdao Wu   +26 more
doaj   +1 more source

The N‐terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism

Animal Models and Experimental Medicine, Volume 8, Issue 1, Page 114-125, January 2025.
GSDMD‐NTki/wt × Alb‐creki/wt mice showed severe liver damage and hepatocyte vacuolation. The expression of genes involved in the development of liver fibrosis was stronger in the livers of GSDMD‐NTki/wtandAlb‐creki/wt mice. GSDMD‐NT induces fibrosis by mediating lipid metabolism. Abstract Background The emerging incidence of pathogenic liver conditions
Xue Wang, Chunyou Ning, Xingyi Cheng, Zhengzhong Wu, Dongbo Wu, Xuemei Ding, Cunxiang Ju, Zhihang Zhou, Lingfeng Wan, Wei Zhao, Peiliang Shi   +10 more
wiley   +1 more source

Ursolic acid ameliorates CCl4‐induced liver fibrosis through the NOXs/ROS pathway

Journal of Cellular Physiology, Volume 233, Issue 10, Page 6799-6813, October 2018., 2018
UA induces the proliferation of HCs, promotes the apoptosis of HSCs, and prevents the activation of KCs in vivo by reducing the expression of NOXs/ROS in HCs, HSCs, KCs. UA also partly improves phagocytosis of KCs and has no effect on host defense function. Liver fibrosis is a reversible wound‐healing response that occurs after liver injury.
Dakai Gan, Wang Zhang, Chenkai Huang, Jiang Chen, Wenhua He, Anjiang Wang, Bimin Li, Xuan Zhu   +7 more
wiley   +1 more source

Acute Appendicitis Secondary to Intestinal Schistosomiasis

Case Reports in Surgery, Volume 2025, Issue 1, 2025.
Schistosomiasis is a parasitic disease caused by blood flukes commonly found in sub‐Saharan Africa and select other areas in Asia and the Americas. The disease can manifest in a wide range of acute and chronic conditions, rarely presenting as acute appendicitis.
Ethan Shyu, Luis Arias-Espinosa, Gabriele Barrocas, Scott Weisenberg, Flavio Malcher, Paola De Nardi   +5 more
wiley   +1 more source

Multi-omics analyses of Bacillus amyloliquefaciens treated mice infected with Schistosoma japonicum reveal dynamics change of intestinal microbiome and its associations with host metabolism.

PLoS Neglected Tropical Diseases
BackgroundSchistosomiasis japonica is a serious threat to human health. It causes damage to the intestine and liver. Probiotic therapy has been shown to be effective in alleviating intestinal diseases and improving host health.
Hao Chen, Shuaiqin Huang, Siqi Yao, Jingyan Wang, Jing Huang, Zheng Yu   +5 more
doaj   +1 more source

Short-Term Efficacy of Laparoscopic Treatment for Colorectal Cancer in Patients with Schistosomiasis Japonica

Gastroenterology Research and Practice, 2016
Introduction. Schistosomiasis is associated with numerous complications such as thrombocytopenia, liver cirrhosis, portal hypertension, and colitis. To the best of our knowledge, the feasibility and outcomes of laparoscopic colorectal surgery in patients
Zhu Yi, Jiang Hong-Gang, Chen Zhi-Heng, Lu Bo-Hao   +3 more
doaj   +1 more source

Schistosomiasis Chemotherapy, Chemoprevention, and Vaccines: History, Progress, and Priorities

Immunity, Inflammation and Disease, Volume 12, Issue 11, November 2024.
Schistosomiasis is a major human disease of public health importance. The goal is to provide an overview of the history and advancements in schistosomiasis chemotherapy, chemoprevention, and vaccine research. Praziquantel is effective against all species of schistosomiasis, but schistosomiasis prevalence has largely remained unaffected, due to ...
Alaa Oqalaa E. Alibrahim, Walaa A. Elkholy, Mona M. El‐Derbawy, Noha F. Zahran, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +6 more
wiley   +1 more source