Cognitive control and discourse comprehension in schizophrenia. [PDF]
, 2012 Cognitive deficits across a wide range of domains have been consistently observed in schizophrenia and are linked to poor functional outcome (Green, 1996; Carter, 2006). Language abnormalities are among the most salient and include disorganized speech as
Boudewyn, Megan A +2 more
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Schizophrenia risk from complex variation of complement component 4
Nature, 2016 Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia’s strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular ...
Aswin Sekar +16 more
semanticscholar +1 more source
Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia
medRxiv, 2020 Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a heritability of 60-80%, much of which is attributable to common risk alleles, suggesting genome-wide association studies can inform our understanding of aetiology.
S. Ripke, J. Walters, M. O’Donovan
semanticscholar +1 more source
Nature Reviews Disease Primers, 2015 Schizophrenia is a chronic psychiatric disorder with a heterogeneous genetic and neurobiological background that influences early brain development, and is expressed as a combination of psychotic symptoms - such as hallucinations, delusions and disorganization - and motivational and cognitive dysfunctions.
Kahn, René S. +10 more
openaire +5 more sources
Rethinking Schizophrenia in the Context of Normal Neurodevelopment
Frontiers in Cellular Neuroscience, 2013 The schizophrenia brain is differentiated from the normal brain by subtle changes, with significant overlap in measures between normal and disease states. For the past 25 years, schizophrenia has increasingly been considered a neurodevelopmental disorder.
Vibeke Sorensen Catts +39 more
doaj +1 more source
Increased Macrophages and C1qA, C3, C4 Transcripts in the Midbrain of People With Schizophrenia
Frontiers in Immunology, 2020 Increased cytokine and inflammatory-related transcripts are found in the ventral midbrain, a dopamine neuron-rich region associated with schizophrenia symptoms.
Tertia D. Purves-Tyson +12 more
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A novel DRD2 single-nucleotide polymorphism associated with schizophrenia predicts age of onset: HapMap tag-sincle-nucleotide polymorphism analysis [PDF]
, 2012 Background: Dopamine D2 receptor (DRD2) is thought to be critical in regulating the dopaminergic pathway in the brain which is known to be important in the aetiology of schizophrenia. It is therefore not surprising that most antipsychotic medication acts
Hughes, Ian +5 more
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The COVID-19 Global Pandemic: Implications for People With Schizophrenia and Related Disorders
Schizophrenia bulletin, 2020 The coronavirus disease-19 (COVID-19) global pandemic has already had an unprecedented impact on populations around the world, and is anticipated to have a disproportionate burden on people with schizophrenia and related disorders.
Nicole Kozloff +3 more
semanticscholar +1 more source
Abnormal Task Modulation of Oscillatory Neural Activity in Schizophrenia
Frontiers in Psychology, 2013 Schizophrenia patients have deficits in cognitive function that are a core feature of the disorder. AX-CPT is commonly used to study cognition in schizophrenia, and patients have characteristic pattern of behavioral and ERP response.
Elisa C Dias +6 more
doaj +1 more source
Alterations in functional brain network structure induced by subchronic phencyclidine (PCP) treatment parallel those seen in schizophrenia [PDF]
, 2010 of poster presentation shown at the 2nd Biennial Schizophrenia International Research Conference on Alterations in functional brain network structure induced by subchronic phencyclidine (PCP) treatment parallel those seen in ...
Dawson, Neil +3 more
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