Results 41 to 50 of about 1,069,369 (339)

Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far? [PDF]

, 2013
In light of the number of studies conducted to examine the treatment of cognitive impairment associated with schizophrenia (CIAS), we critically reviewed recent CIAS trials.
Buchanan, Robert W, Dugar, Ashish, Keefe, Richard SE, Marder, Stephen R, Schooler, Nina R, Stewart, Michelle, Zivkov, Milana   +6 more
core  

Subanesthetic ketamine treatment promotes abnormal interactions between neural subsystems and alters the properties of functional brain networks [PDF]

, 2014
Acute treatment with subanesthetic ketamine, a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, is widely utilized as a translational model for schizophrenia. However, how acute NMDA receptor blockade impacts on brain functioning at a
A Bifone, A Marsman, A Nikiforuk, A Stuchlik, A Verma, AC Lahti, AK Malhotra, AS Meyer-Lindenberg, B Moghaddam, BM Roberts, Brian J Morris, C Chih-Liang, C Corradi-Dell'Acqua, C De la Fuente-Sandoval, C Mirjana, Carsten M. Klingner, CJA Morgan, DC D’Souza, Desmond J Higham, DS Bassett, FR Sharp, FX Vollenweider, FX Vollenweider, G Paxinos, GD Honey, GE Duncan, H Metzer, J Cosgrove, J McCulloch, JA Saunders, JD Jentsch, JH Krystal, JH Krystal, JJ Kim, JM McNally, Judith A Pratt, JW Langsjo, JW Moore, K Hill, K Skoblenick, L Deserno, LJ Steward, M Amargos-Bosch, M Hauser, M Irifune, M Niesters, Martin McDonald, ME Jackson, ME Lynall, N Dawson, N Dawson, N Dawson, N Dawson, N Lindefors, N Pitsikas, ND Woodward, Neil Dawson, NR Driesen, R Galci, R Schlösser, RC Welsh, S Benetti, S Marenco, S Micheloyannis, S Miyamoto, SA Spence, SM Cochran, SP Kulikova, SY Yang, T Kos, T Kubota, Tatsunobu Natsubori, VP Bakshi, X Xiao, Y Li, Y Liu, Y Zhang, Y Zhou   +77 more
core   +1 more source

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source

From lived experience to leadership: establishing a stakeholder advisory board to guide first-episode psychosis research and services

BMC Health Services Research
Background Advisory boards incorporating people with lived experience (PWLE) with psychosis substantially enhance first-episode psychosis (FEP) services.
B. Priyadharshni, S. Jagadeesan, Krishna Priya, Greeshma Mohan, N. Anerudh, R. Krishnaveni, Vijaya Raghavan   +6 more
doaj   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Effectiveness of Virtual - Compensatory Cognitive Training (V-CCT) for improving cognition in persons with schizophrenia - a multi- centre randomized controlled trial

Trials
Background Cognitive deficits are the core component in persons with schizophrenia which impacts their socio-occupational functioning. Also, cognitive deficits cause significant impairment with the person’s quality of life [3].
Sonia Sims, Suvarna Jyothi Kantipudi, Yogitha Ashok, B. Nisha, Subhashini Gopal, Elsa Joseph, S. Amritha, Lakshmi Venkatraman, Pratiksha Venkatasubramanian, Padmavati Ramachandran   +9 more
doaj   +1 more source

Prevalence of physical comorbidities among long-term psychiatric inpatients: A single centre study from South India

Indian Journal of Mental Health and Neurosciences, 2021
Array
V Narmadha, A Akshaya, Vijaya Raghavan, P Poornachandrika   +3 more
doaj   +1 more source

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. [PDF]

, 2019
We generated cortical interneurons (cINs) from induced pluripotent stem cells derived from 14 healthy controls and 14 subjects with schizophrenia. Both healthy control cINs and schizophrenia cINs were authentic, fired spontaneously, received functional ...
Apud, Jose, Berman, Karen F, Bin Kim, Woong, Cho, Jun-Hyeong, Chung, Sangmi, Cohen, Bruce M, Cote, Sarah E, Coyle, Joseph T, Eggan, Kevin C, Eisenberg, Leonard M, Fukuda, Emi, Ghosh, Sulagna, Hirayama, Teruyoshi, Huang, Weihua, Kim, Hae-Young, Lanz, Thomas A, McPhie, Donna L, Moghadam, Alexander A, Nguyen, Christine, Ni, Peiyan, Noh, Haneul, Noyes, Elizabeth, Ongur, Dost, Park, James M, Park, Joshua J, Parsons, Teagan, Perlis, Roy H, Rapoport, Judith L, Shao, Zhicheng, Stanton, Patric K, Straub, Richard E, Weinberger, Daniel R, Xi, Hualin Simon, Yagi, Takeshi, Yin, Changhong, Zhao, Joyce, Zheng, Kelvin   +36 more
core   +1 more source

A Systematic Review of the Soteria Paradigm for the Treatment of People Diagnosed With Schizophrenia [PDF]

, 2008
Background: The “Soteria paradigm” attempts to support people diagnosed with schizophrenia spectrum disorders using a minimal medication approach. Interest in this approach is growing in the United Kingdom, several European countries, North America, and ...
Calton, Tim, Ferriter, Michael, Huband, Nick, Spandler, Helen   +3 more
core   +2 more sources

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source