Results 41 to 50 of about 21,133 (314)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Conceptions de l’ornement en quête de discours scientifique
Perspective, 2020 The three books under review here all throw important new light on the complex history of ornament in the West. Clare Guest’s study of the understanding of ornament in the Renaissance is an ambitious and highly learned attempt to recover the pre-history ...
Caroline van Eck
doaj +1 more source
Francisco Suárez on Eternal Truths, Eternal Essences, and Extrinsic Being [PDF]
, 2017 It is necessarily true that water is H2O, but it is a contingent fact that there is any water at all. Water therefore seems ill suited to ground the necessary truth that water is H2O.
Embry, Brian
core +2 more sources
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Analogy, Semantics, and Hermeneutics: The “Concept versus Judgment” Critique of Cajetan’s De Nominum Analogia [PDF]
, 2003 Page range: 241 ...
Hochschild, Joshua
core +2 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
The Notion of "communis schola" in the Thought of Jean Gerson (1363–1429)
Studia Ceranea, 2021 The article aims to analyze the meaning and the role of the notion of communis schola in the theological and ecclesiological thought of Jean Gerson (1363–1429), Chancellor of the University of Paris, schoolman influent in every intellectual debate of his
Luciano Micali
doaj +1 more source
Hegel's Eurocentric Triads of Dialectics and its Transformation to Kelly's Planetary Paradigm [PDF]
, 2018 This article introduces Hegel's Eurocentric philosophy of dialectics in the 19th century and its transformation to Kelly’s planetary paradigm at the turn of the 20th-21st century.
ma, Z. G.
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source