Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
, 2010 This descriptive study reports on the structure and implementation of a school wide professional development model in a southwest public elementary school.
Lambson, Dawn, Steeg, Susanna M.
core
Leading improvement through the challenges and opportunities in school and across schools [PDF]
, 2010 "This booklet is the fifth in a series of professional development materials entitled ‘Leading Improvement’. It is intended to inform ongoing discussions between the National Strategies, local authorities, School Improvement Partners (SIPS) and ...
core
Ledelsespraksis i oppstarten av skolers arbeid for utvikling av tilpasset opplæring
Forskning og ForandringDenne artikkelen rapporterer fra en studie der vi undersøker ledelsespraksiser i oppstarten av skolers arbeid for utvikling av tilpasset opplæring iverksatt på initiativ fra skoleeieren.
Vegard Yttergård +1 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Securing a College Prep Curriculum for All Students [PDF]
, 2009 Presents a case study of community organizing for school reform by Los Angeles' Community Coalition: how its intergenerational campaign for college preparatory classes shaped leadership development, district policy, school capacity, and student ...
Kavitha Mediratta +2 more
core
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Development in the early years : Its importance for school performance and adult outcomes [Wider Benefits of Learning Research Report No. 20] [PDF]
, 2006 Early development of children’s intellectual, social and physical abilities has the potential to affect their long term achievement, beyond the initial introduction to the classroom, through their school lives and into adulthood.
Duckworth, Kathryn, Feinstein, Leon
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source