Results 221 to 230 of about 51,731 (281)

Imeglimin improves hyperglycemia and hypoglycemia‐induced cell death and mitochondrial dysfunction in immortalized adult mouse Schwann IMS32 cells

Journal of Diabetes Investigation, Volume 16, Issue 9, Page 1586-1596, September 2025.
Imeglimin reduces Schwann cell death by suppressing Complex I and oxidative stress, which may prevent diabetic neuropathy by protecting mitochondrial functions. ABSTRACT Aims/Introduction Imeglimin, a novel oral antidiabetic drug, enhances glucose‐stimulated insulin secretion, improves insulin sensitivity, and reduces mitochondrial reactive oxygen ...
Ayako Kato, Wataru Nihei, Hideji Yako, Yasuaki Tatsumi, Tatsuhito Himeno, Masaki Kondo, Yoshiro Kato, Jiro Nakamura, Hideki Kamiya, Kazunori Sango, Koichi Kato   +10 more
wiley   +1 more source

Erratum: Effects and molecular mechanisms of <i>Achyranthes bidentata</i> polypeptide k on proliferation of Schwann cells. [PDF]

Ann Transl Med
Editorial Office.
europepmc   +1 more source

Clinical value of high‐frequency ultrasound and serum miR‐92a‐3p in diabetic peripheral neuropathy

Journal of Diabetes Investigation, Volume 16, Issue 9, Page 1692-1703, September 2025.
Serum miR‐92a‐3p and CSAs of median, ulnar, and tibial nerves are elevated in DPN patients. Their combination has high diagnostic significance in identifying DPN in T2DM patients and assessing its severity. ABSTRACT Aims/Introduction Cross‐sectional area (CSA) by high‐frequency ultrasound (HF‐US) detects morphologic changes in neuropathy. microRNA (miR)
Chunmei Qiao, Zhenjiao Liu, Boran Wang, Xin Wang, Zifu Zhao, Hui Wang, Xiaolei Wang   +6 more
wiley   +1 more source

Digenesis in Charcot–Marie–Tooth Disease: Impact of Combined Mutations in the MFN2 and GDAP1 Genes

Journal of the Peripheral Nervous System, Volume 30, Issue 3, September 2025.
ABSTRACT Background and Aims Charcot–Marie–Tooth disease (CMT) is a rare hereditary neuropathy that affects peripheral nerves in the upper and lower limbs. To distinguish between the different forms of the disease, electrophysiological criteria are essential.
Endrit Shumeri, Ebrahem Mandorah, Nathalie Martini, Amandine Boyer, Cécile Halbert, Angela Puma, Annabelle Chaussenot, Emilien Delmont, Karine N'guyen, Shahram Attarian, Nathalie Bonello‐Palot   +10 more
wiley   +1 more source

Mitochondrial Trifunctional Protein Deficiency due to HADHA Variants Masquerading as Charcot–Marie–Tooth Disease

Journal of the Peripheral Nervous System, Volume 30, Issue 3, September 2025.
ABSTRACT Background and Aims Mitochondrial trifunctional protein deficiency (MTPD) is an inherited disorder of fatty acid β‐oxidation caused by mutations in HADHA or HADHB genes. It typically presents with cardiomyopathy or hepatic failure in early childhood; however, it may rarely present in adulthood with the neuromyopathic form.
Farkhanda Qaiser, John McHugh, Gerard Mullins, Michael Farrell, Loai Shakerdi, James O. Byrne, Sinéad M. Murphy   +6 more
wiley   +1 more source

Hydrogen Peroxide Modulates the Timely Activation of Jun and Erk in Schwann Cells at the Injury Site and Is Required for Motor Axon Regeneration. [PDF]

Cells
Negro S, Baggio C, Tonellato M, Stazi M, D'Este G, Megighian A, Montecucco C, Rigoni M.   +7 more
europepmc   +1 more source

Pharmacological Targeting of Hyperpolarization‐Activated Cyclic Nucleotide‐Gated Cation Channels on Bladder Afferent Sensory Transmission

LUTS: Lower Urinary Tract Symptoms, Volume 17, Issue 5, September 2025.
ABSTRACT Objective This study aimed to investigate the potential role of cesium chloride (CsCl), ivabradine (IVA), and isoproterenol (ISO) on the sensory transmission of bladder afferents to graded urinary bladder distension (UBD). We specifically selected these drugs to target the hyperpolarization‐activated cyclic nucleotide‐gated (HCN) cation ...
Eric Woon, Jorge Villalobos Santeli, Jia Liu, Longtu Chen, George Kuchel, Bin Feng   +5 more
wiley   +1 more source

Influences of physical stimulations on the migration and differentiation of Schwann cells involved in peripheral nerve repair. [PDF]

Cell Adh Migr
Sun Q, Mu X, Gao Q, Wang J, Hu M, Liu H.
europepmc   +1 more source

Decoding Pain: Next‐Generation In Vitro Systems for Mechanistic Insights and Drug Discovery

The FASEB Journal, Volume 39, Issue 16, 31 August 2025.
Developing an in vitro pain model that mimics essential features of the in vivo pain circuit requires careful consideration of multiple components and choices. These include selecting the cellular population for the model, choosing from the origin of nociceptors and other cells that are cultured, deciding between 3D or 2D dimensions, designing the ...
Dara Khosrowshahi, Liesbet Lagae, Johanna Bolander   +2 more
wiley   +1 more source