Results 61 to 70 of about 68,795 (281)

Embryonic Corneal Schwann Cells Express Some Schwann Cell Marker mRNAs, but No Mature Schwann Cell Marker Proteins [PDF]

Investigative Opthalmology & Visual Science, 2009
Embryonic chick nerves encircle the cornea in pericorneal tissue until embryonic day (E)9, then penetrate the anterior corneal stroma, invade the epithelium, and branch over the corneal surface through E20. Adult corneal nerves, cut during transplantation or LASIK, never fully regenerate.
Abigail H, Conrad, Michael, Albrecht, Maya, Pettit-Scott, Gary W, Conrad   +3 more
openaire   +2 more sources

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Edaravone combined with Schwann cell transplantation may repair spinal cord injury in rats

Neural Regeneration Research, 2015
Edaravone has been shown to delay neuronal apoptosis, thereby improving nerve function and the microenvironment after spinal cord injury. Edaravone can provide a favorable environment for the treatment of spinal cord injury using Schwann cell ...
Shu-quan Zhang, Min-fei Wu, Zhe Piao, Jin Yao, Ji-hai Li, Xin-gang Wang, Jun Liu   +6 more
doaj   +1 more source

Notch and Schwann cell transformation [PDF]

Oncogene, 2004
Benign plexiform neurofibromas in NF1 patients can transform spontaneously into malignant peripheral nerve sheath tumors (MPNSTs). Although mutations in the p53 gene have been found in a subset of MPNSTs and mouse models support a role for p53 mutations in malignant conversion, we found that each of three Schwann cell lines derived from human MPNSTs ...
Yiwen, Li, Prakash K, Rao, Rong, Wen, Ying, Song, David, Muir, Peggy, Wallace, Samantha J, van Horne, Gihan I, Tennekoon, Tom, Kadesch   +8 more
openaire   +2 more sources

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

miR-148b-3p promotes migration of Schwann cells by targeting cullin-associated and neddylation-dissociated 1

Neural Regeneration Research, 2016
MicroRNAs (miRNAs) are small, non-coding RNAs that negatively adjust gene expression in multifarious biological processes. However, the regulatory effects of miRNAs on Schwann cells remain poorly understood.
Tian-mei Qian, Li-li Zhao, Jing Wang, Ping Li, Jing Qin, Yi-sheng Liu, Bin Yu, Fei Ding, Xiao-song Gu, Song-lin Zhou   +9 more
doaj   +1 more source

IPSC-Derived Sensory Neurons Directing Fate Commitment of Human BMSC-Derived Schwann Cells: Applications in Traumatic Neural Injuries

, 2023
The in vitro derivation of Schwann cells from human bone marrow stromal cells (hBMSCs) opens avenues for autologous transplantation to achieve remyelination therapy for post-traumatic neural regeneration.
Wing-Yui Liu, Lam, G, Liu, WY, Tam, KW, Kenneth Lap-Kei Wu, Wai-Ting Wong, Ying-Shing Chan, Wong, WT, Shum, DKY, Cai, S, Liang, XT, Sa Cai, Graham Ka-Hon Shea, Maximilian Tak-Sui Li, Xiaotong Liang, Wong, CY, Daisy Kwok-Yan Shum, Wu, KLK, Guy Lam, Li, MTS, Kin-Wai Tam, Cheuk-Yin Wong, Shea, GKH, Chan, YS   +23 more
core   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Schwann cell dysfunction in uraemia [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1970
Examination of individual sural nerve fibres revealed segmental demyelination, in 10 out of 12 subjects with uraemia. Peripheral neuropathy was present in only two cases. The complex biochemical changes occurring with dialysis unmask the underlying demyelination in subjects with a latent neuropathy.
J J, Dinn, D L, Crane
openaire   +2 more sources