Results 81 to 90 of about 51,731 (281)

Severe Nerve Enlargement in SOS2‐Related Noonan Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan syndrome is a genetic multisystem congenital disorder, caused by pathogenic variants in genes that encode components of the RAS/MAPK signaling pathway. Pathogenic variants in SOS2 represent less than 2% of cases with NS. The phenotype includes a particularly high prevalence (65%) of lymphatic disease. Recently, severe nerve enlargements
Erika Leenders, Fieke Draaisma, Corrie E. Erasmus, Catelijne Coppens, Lotte E. R. Kleimeier, Melanie Burgers, Tuula Rinne, Martin Zenker, Laura Mazzanti, Wesley Reintjes, Nens van Alfen, Jos M. T. Draaisma   +11 more
wiley   +1 more source

Design and Application of Piezoelectric Conductive Smart Scaffold for Noninvasive Neural Tissue Regeneration via Custom‐Made In Vitro Mechano‐Stimulator

Advanced NanoBiomed Research, EarlyView.
Schematic illustration showing the design of the developed invitro mechano stimulator (IMS) and the electrospun nanofiber‐based piezoelectric and conductive nerve conduit (PCNC) that can self‐generate electrical stimulations analogous to neural tissues. IMS provided vital electrical cues for the neural cells to attach, align and proliferate on the PCNC
Afeesh Rajan Unnithan, Vignesh Krishnamoorthi Kaliannagounder, Nagamalleswara Rao Alluri, Chan Hee Park, Pandiyarasan Veluswamy, Arathyram Ramachandra Kurup Sasikala   +5 more
wiley   +1 more source

CD8+ T Cell-Mediated Cytotoxicity toward Schwann Cells Promotes Diabetic Peripheral Neuropathy

Cellular Physiology and Biochemistry, 2013
Background: Damage to Schwann cells has been reported in the development of diabetic peripheral neuropathy (DPN), but how Schwann cells are damaged has not been elucidated.
Wei Tang, Qian Lv, Xiang-fang Chen, Jun-jie Zou, Zhi-min Liu, Yong-quan Shi   +5 more
doaj   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Eugenia brasiliensis: Analysis of the Chemical Profile and Evaluation of Cytotoxic Potential

Chemistry &Biodiversity, EarlyView.
Leaves of Eugenia brasiliensis were dried, crushed and macerated with polarity increment. The antiporliferative and anti‐migratory potential and the cell cycle were evaluated. 28 compounds were tentatively identified by mass sceptrometry. ABSTRACT This work evaluated the antiproliferative potential of Eugenia brasiliensis leaf extracts against the HeLa
Giovana G. F. V. de Oliveira, Milena F. Longue, Letícia M. R. Pescinelli, Thiago S. Charret, Thalya S. R. Nogueira, Mariana T. M. Pereira, Ivo J. C. Vieira, Lucas S. Abreu, Vinicius D. B. Pascoal, Aislan C. R. F. Pascoal   +9 more
wiley   +1 more source

Matrix metalloproteinase 7 promoted Schwann cell migration and myelination after rat sciatic nerve injury

Molecular Brain, 2019
Schwann cells experience de-differentiation, proliferation, migration, re-differentiation and myelination, and participate in the repair and regeneration of injured peripheral nerves.
Hongkui Wang, Ping Zhang, Jun Yu, Fuchao Zhang, Wenzhao Dai, Sheng Yi   +5 more
doaj   +1 more source

Chemical Conversion of Human Fibroblasts into Functional Schwann Cells

Stem Cell Reports, 2014
Direct transdifferentiation of somatic cells is a promising approach to obtain patient-specific cells for numerous applications. However, conversion across germ-layer borders often requires ectopic gene expression with unpredictable side effects.
Eva C. Thoma, Claudia Merkl, Tobias Heckel, Rachel Haab, Frederic Knoflach, Corinne Nowaczyk, Nicholas Flint, Ravi Jagasia, Sannah Jensen Zoffmann, Hoa Hue Truong, Pascal Petitjean, Sebastian Jessberger, Martin Graf, Roberto Iacone   +13 more
doaj   +1 more source

THE RELATIONSHIP BETWEEN AXONS AND SCHWANN CELLS DURING DEVELOPMENT OF PERIPHERAL NERVES IN THE RAT [PDF]

, 1959
Alan Peters, A. R. Muir
openalex   +1 more source

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

Developmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore, Anjali Balakrishnan, Yacine Touahri, Dawn Zinyk, Humna Noman, Satoshi Okawa, Jeff Biernaskie, Carol Schuurmans   +7 more
wiley   +1 more source

Granular cell myoblastoma—a misnomer. Electron microscopic and histochemical evidence concerning its schwann cell derivation and nature (granular cell schwannoma) [PDF]

, 1962
Edwin R. Fisher, Harry Wechsler
openalex   +1 more source