Results 191 to 200 of about 25,360 (296)

Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1

The Journal of Physiology, EarlyView.
Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang, Pabitra Hriday Patra, Jinquan Yang   +2 more
wiley   +1 more source

Piriformis syndrome and lumbosacral radiculopathy: An overlooked coexistence. [PDF]

Turk J Phys Med Rehabil
Topçu YB, Palamar D, Terlemez R, Akgün K, Özekli Mısırlıoğlu T.   +4 more
europepmc   +1 more source

Peripheral regeneration of Aβ low‐threshold mechanoreceptors is limited despite activation of regenerative transcriptional pathways

The Journal of Physiology, EarlyView.
Abstract figure legend The regeneration of Aβ low‐threshold mechanoreceptors (Aβ‐LTMRs), sensory neurons responsible for discriminative touch, has not previously been explored. Here, we took advantage of the selective expression of Calb1 in Aβ‐LTMRs to generate two genetic mouse models for studying their regenerative response after nerve injury.
Sara Bolívar, Natàlia Martínez‐Mateu, David Ovelleiro, Esther Udina   +3 more
wiley   +1 more source

Sciatica as an atypical initial presentation of multiple myeloma: a case report. [PDF]

AME Case Rep
Juma AM, Shamtoot Q, Juma MM, Flood J.
europepmc   +1 more source

Integrated Phytochemical Characterisation, Pharmacological Evaluation and Computational Investigation of Acampe papillosa Stem Extract

Analytical Science Advances, Volume 7, Issue 2, December 2026.
The pharmacological potential of the methanolic stem extract of Acampe papillosa is evaluated using in vivo and in silico approaches. The extract demonstrates significant anxiolytic, sedative, anti‐inflammatory, and antipyretic activities in experimental models, while molecular docking supports the observed biological effects through favorable ...
Qurratul Ain Sadia, Sadia Tamanna Tamim, Faruq Mohammed Tashriq, Nasir Uddin, Fatematus Zhohara Alam Hima, Ulfat Sobha Surat, Mily Khastagir, Muhammad Abdul Jalil, Md. Hossain Rasel, Arman Ullah Rafi, S. M. Moazzem Hossen   +10 more
wiley   +1 more source

Breast Cancer Metastases Presenting as Musculoskeletal Complaints. [PDF]

Cureus
Chu EC, Ng L.
europepmc   +1 more source

Schwann Cell‐Specific ATG7‐Dependent Autophagy Protects Myelin in a Mouse Model of Krabbe Disease

Glia, Volume 74, Issue 12, December 2026.
Krabbe disease (KD) is caused by mutations in GALC and deregulated lysosomal function in Schwann cells (SCs). Using a SC‐specific Galc‐cKO mouse, we identified altered autophagy in SCs during KD progression. Further ablation of Atg7 in SCs of KD worsened disease severity.
Narayan Dhimal, Aditya Sidharth, Jiajun Zhang, Trina Rudra, Edward Hurley, Pablo M. Paez, Fraser J. Sim, Daesung Shin, M. Laura Feltri   +8 more
wiley   +1 more source

Exploring Causal Associations Between Plasma Metabolites and Sciatica: A Two-Sample Mendelian Randomization Analysis. [PDF]

J Pain Res
Yu S, Wei Q, Luo Y, Wu G.
europepmc   +1 more source

A Novel MR Elastography Device for Preclinical Applications From Spheroids to Rodents: Design, Validation, and Performance Evaluation

NMR in Biomedicine, Volume 39, Issue 11, November 2026.
MR elastography (MRE) noninvasively assesses tissue biomechanics, but preclinical research suffers from diverse hardware solutions, hindering reproducibility and comparability. This study introduces a versatile preclinical MRE device for imaging rodents, ex vivo samples, and spheroids/organoids.
Gabrielle Mangin, Hannah Fels‐Palesandro, Valéria Bisio, Nicolas Dulphy, Karl Balabanian, Inas H. Faris, Andrea Federici, Asma Boumaza, Marguerite Ducamp, Roland Zerelles, Valérie Vilgrain, Valérie Paradis, Giacomo Annio, Katharina Schregel, Ralph Sinkus   +14 more
wiley   +1 more source

Efficacy of Multimodal Rehabilitation Protocol with High-Force Machine Spinal Decompression Therapy in Chronic Low Back Pain with Sciatica Due to Lumbar Disc Herniation: A Pre-Post Observational Study. [PDF]

Healthcare (Basel)
Nado BBN, Schuster S.
europepmc   +1 more source