Results 201 to 210 of about 21,081 (256)

Recombinant Artemin‐Fc Fusion Protein Attenuates TLR4/NF‐κB‐Associated Neuroinflammation and Modulates Inhibitory/Excitatory Synaptic Marker Expression After Spinal Cord Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Intrathecal ARTN‐Fc treatment attenuates TLR4/NF‐κB‐associated neuroinflammation, promotes microglia/macrophage polarization towards an anti‐inflammatory phenotype, and improves functional recovery after spinal cord injury. ARTN‐Fc also modulates inhibitory/excitatory synaptic marker expression in the L4–L5 spinal dorsal horn, which may contribute to ...
Wenjie Lu, Yurong Tu, Renkai Wang, Minghao Jiang, Junyu Zhuang, Jiahui Song, Ping Wu, Sunren Sheng, Sipin Zhu, Zhouguang Wang   +9 more
wiley   +1 more source

Exploring Rafe's Sciatica: Investigating the Link Between Spondyloarthropathy and Non-discogenic Sciatica. [PDF]

Cureus
Rahman MM, Ferdous N, Hasan MM, Sarker S, Farhad S.   +4 more
europepmc   +1 more source

Scutellarin Alleviates Neuronal Apoptosis After Ischemia and Hypoxia via the HIF‐1α–CX3CR1 Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
In this study, we established a mouse model of middle cerebral artery occlusion and cultured primary neurons to evaluate the protective effects of scutellarin against ischemia and hypoxia, specifically analyzing CX3CR1 expression and its role in apoptosis.
Jingchun Pei, Bin Hu, Zhonghui Wen, Cheng Wan, Fuqing Zhang, Shaoxiang Li, Lei Wang, Zhigao Li, Zhiwei Tang   +8 more
wiley   +1 more source

Left-Sided Sciatic Nerve Endometriosis Presenting As Chronic Thigh Pain and Muscle Atrophy: A Case Report. [PDF]

Cureus
Samadov P, Aliyev K, Eldarova I, Hajiyev A, Hasanov E.   +4 more
europepmc   +1 more source

The Combination of Buprenorphine and Pregabalin in the Management of Peripheral Neuropathic Pain: A Phase IV, Randomized, Double‐Blind and Placebo‐Controlled Clinical Trial

European Journal of Pain, Volume 30, Issue 7, August 2026.
ABSTRACT Background Pharmacological combinations are commonly used for treating refractory neuropathic pain, although supporting evidence is lacking. Gabapentinoid‐opioid combination is one of the most studied; however, their efficacy is inconsistent across clinical trials.
Larissa I. Moreira, Pedro N. Martins, Manoel J. Teixeira, Daniel C. de Andrade, Gabriel T. Kubota   +4 more
wiley   +1 more source

Piriformis Syndrome Is Often Overlooked as a Cause of Gluteal Pain and Sciatica: Diagnostic Challenges and the Role of Imaging-A Narrative Review. [PDF]

HSS J
Alrabai HM, Alrashidi Y, AlEtebi RAA, Mufti TMA, Alali MYA, Alnazhan ASA.   +5 more
europepmc   +1 more source

Longitudinal Tracking of Astrocyte Reactivity During the Development of Chronic Orofacial Neuropathic Pain Using [18F]‐SMBT‐1 Positron‐Emission Tomography

Glia, Volume 74, Issue 8, August 2026.
Using [18F]‐SMBT‐1 PET, we longitudinally tracked MAO‐B–expressing reactive astrocytes during orofacial neuropathic pain development in rats, revealing region‐ and time‐specific astrocyte activation during pain chronification. ABSTRACT Chronic neuropathic pain represents a significant global health burden and is hypothesized to be maintained by an ...
Lewis S. Crawford, James W. M. Kang, OIivia I. Davanzo, Hyunsol Lim, Sabrina Salberg, Marissa Srgo, Crystal Li, Gaelle M. Emvalomenos, Bianca Jupp, Matthew Long, Wayne Noonan, Mohammad B. Haskali, Richelle Mychasiuk, Kevin A. Keay, Luke A. Henderson   +14 more
wiley   +1 more source

Comment on "Efficacy and Safety of Acupuncture and Acupuncture-Combined Therapies in the Treatment of Sciatica Caused by Lumbar Disc Herniation: A Network Meta-Analysis" [Letter]. [PDF]

J Pain Res
Tang Y, Chen B.
europepmc   +1 more source

Selective Small‐Molecule AdipoR1 Agonist 3‐Hydroxy Pterocarpan Salt (CDRI‐1709S) Ameliorates Skeletal Muscle Atrophy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle atrophy is a frequent comorbidity of metabolic disorders and chronic diseases, and despite its high prevalence, no pharmacological therapy is available, representing a major unmet clinical need. Adiponectin and its receptors are key regulators of skeletal muscle metabolism, mitochondrial function and myogenesis, yet ...
Md. Rameez Moin, Shyamal Pal, Shubhrajyoti Das, Pallavi Awasthi, Anushka Talukdar, Akhilesh Kumar, Shruti Suhas Varode, Nikhil Nikolas, Shamima Khatoon, Madhav Nilkanth Mugale, Rajdeep Guha, Sabyasachi Sanyal, Atul Goel   +12 more
wiley   +1 more source

Post COVID-19 treated with AstraZeneca vaccine exacerbates arthritis with susceptibility to herpes in an older woman: A case report. [PDF]

Medicine (Baltimore)
Guzman DC, Brizuela NO, Herrera MO, Peraza AV, García EH, Jimenez FT, Juarez Olguin H.   +6 more
europepmc   +1 more source