Results 141 to 150 of about 196,305 (346)

An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B‐Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations

Small Methods, EarlyView.
This work presents an integrated set of methods to evaluate the efficacy of asparaginase formulations against B‐cell Acute Lymphoblastic Leukemia (ALL) in mice, including the establishment of an ALL murine model, an amino acid depletion study using high‐performance liquid chromatography (HPLC), and comprehensive assessment of antibody production ...
Julien Santelli, Annie Y. Heble, Connor Endsley, Adam Woodward, Nazia Hafeez, Naomi Winick, Jacques Lux   +6 more
wiley   +1 more source

Solamargine induces acute myeloid leukemia differentiation through TLR8 activation

VIEW, EarlyView.
SM, a steroidal alkaloid from Solanum nigrum L. has shown anticancer effect on various kinds of human cancer cells, yet its effect on leukemia cells remains unclear. This study examines antileukemic activities of SM in AML cells. Results indicate SM inhibits growth and promotes apoptosis of AML cells.
Qiaoyan Han, Yuting Chen, Zheyi Li, Yonglin Peng, Zhehan Hu, Yuliang Deng, Yanli Fu, Ming Cheng, Sheng Tan, Jing Tian, Xiaodong Zhao, Miao Sun   +11 more
wiley   +1 more source

An Atypical Severe Combined Immunodeficiency (SCID) Case Diagnosis Complicated by Alternative Care in the Era of Newborn Screening (NBS) for SCID [PDF]

, 2017
Taylor Alberdi, Johana B Castro-Wagner, Bhumika Patel, Sonia Joychan, David Hobbs Lindsey, Frederico R. Laham, Krisztián Csomós, Boglárka Ujházi, Carla Duff, Jessica Trotter, Jack Bleesing, Attila Kumánovics, Yenhui Chang, Jamie H. Hale, Panida Sriaroon, Greg Hale, Benjamin Oshrine, Luigi D. Notarangelo, Roshini S. Abraham, Anne Marie Comeau, Aleksandra Petrovič, Jennifer W. Leiding, Jolán E. Walter   +22 more
openalex   +1 more source

Childhood Maltreatment and Cognitive Functioning in Bipolar Disorder: A Systematic Review and Meta‐Analysis

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Aims Characterising the association between childhood maltreatment (CM) and cognitive functioning in bipolar disorder (BD) is crucial for improving the understanding of how early environmental risk factors impact the presentation of the disorder.
Natalia E. Fares‐Otero, Anaid Pérez‐Ramos, Ricardo Lopez‐Escribano, Sara Martin‐Parra, Luis Alameda, Sarah L. Halligan, Kamilla Woznica Miskowiak, Eduard Vieta   +7 more
wiley   +1 more source

Hematopoietic stem cell–engrafted NOD/SCID/IL2Rγnull mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses [PDF]

, 2006
Satoru Watanabe, Kazuo Terashima, Shinrai Ohta, Shigeo Horibata, Misako Yajima, Yoko Shiozawa, Md. Zahidunnabi Dewan, Zhong Sheng Yu, Mamoru Ito, Tomohiro Morio, Norio Shimizu, Mitsuo Honda, Naoki Yamamoto   +12 more
openalex   +1 more source

Cognitive and Psychomotor Processing Speed in Medication‐Naïve Individuals With First‐Episode of Psychosis: The Role of Peripheral Inflammatory Markers

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background and Hypothesis Deficits in processing speed (PS) and psychomotor speed (PMS) are core cognitive impairments in schizophrenia spectrum disorders, including first‐episode psychosis (FEP). Neuroinflammation has been proposed as a potential contributor to these deficits.
Ángel Yorca‐Ruiz, Carlos Martínez Asensi, Rebeca Magdaleno Herrero, Alexandre Díaz‐Pons, Víctor Ortiz‐García de la Foz, Luis Manuel Fernández Cacho, Ana Catalán Alcantara, Benedicto Crespo‐Facorro, Rosa Ayesa‐Arriola   +8 more
wiley   +1 more source

Predicting Cognitive Change During Treatment for Inpatient Depression: Secondary Analysis From a Randomized Controlled Trial

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Individuals hospitalized with depression are particularly impacted by cognitive impairment. Identifying variables that predict improvements in cognition across treatment may inform more targeted and effective treatment approaches. We conducted secondary analyses to investigate baseline predictors of objective cognitive change in a
Zoe A. Odering, Jennifer Jordan, Cameron J. Lacey, Christopher M. Frampton, Richard J. Porter, Katie M. Douglas   +5 more
wiley   +1 more source

Newborn screening for severe combined immunodeficiency in Malaysia: current status, challenges and progress

Frontiers in Immunology
IntroductionEarly diagnosis of Severe Combined Immunodeficiency (SCID) increases survival outcomes and quality of life while significantly minimizing healthcare burden and costs.
Wai Leng Chang, Wai Leng Chang, Lokman Mohd Noh, Amir Hamzah Abdul Latiff, Amir Hamzah Abdul Latiff, Kent Chee Keen Woo, Intan Hakimah Ismail, Intan Juliana Abd Hamid, Sangeetha Siniah, Mohd Azri Zainal Abidin, Marina Sham, Adiratna Mat Ripen, Mohd Farid Baharin, Asrul Abdul Wahab, Zarina Thasneem Zainudeen, Ilie Fadzilah Hashim, Yee Ming Wong, Yee Ming Wong, Mohamad Qazreen Ahmad Shawaludin, Adli Ali, Adli Ali, Adli Ali, Adli Ali   +22 more
doaj   +1 more source

Lifetime Mixed Depression and Childhood Trauma in Individuals With Bipolar Disorders

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background and Aims Mixed Depression (MxD), characterized by the co‐occurrence of depressive and excitatory symptoms, is a prevalent yet often underdiagnosed presentation in bipolar disorders (BD), with significant implications for prognosis and treatment. Childhood trauma is a key environmental risk factor associated with a more severe course
Francesca Bardi, Mario Pinto, Alessio Simonetti, Marco Di Nicola, Marianna Mazza, Giovanni Manfredi, Georgios D. Kotzalidis, Gabriele Sani, Delfina Janiri   +8 more
wiley   +1 more source

1040. Development of a Novel Xenotransplant Model (NOD/SCID/MPSVII) To Determine the Efficacy of Human Hematopoietic Progenitor Cell-Directed Gene Therapy for a Lysosomal Storage Disease [PDF]

, 2002

openalex   +1 more source