Results 151 to 160 of about 102,493 (259)
Senolytics and exercise: Dual modalities for rejuvenating muscle
The Journal of Physiology, EarlyView.Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican +4 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In lowland mammals that ascend to high elevation, hypoxia‐induced changes in the pulmonary circulation can give rise to hypoxic pulmonary hypertension (HPH) and associated right‐ventricle (RV) hypertrophy. Andean mice with broad elevational ranges have greater heart mass relative to body size at higher elevations, but they ...
Naim M. Bautista +9 more
wiley +1 more source
Comment on "A single-cell digital PCR method tailored for quantification of HBV DNA positive cells in liver biopsy tissues". [PDF]
J Transl MedChen Y, Zhao G, Song J.
europepmc +1 more source
Maturation of spinal motor control through developmental changes in ion currents
The Journal of Physiology, EarlyView.Abstract figure legend Ion channels of spinal neurons have been shown to change during development in a wide range of species. These changes occur at specific stages of development. An important developmental process is the maturation of motor control by which the body acquires new movements or refines movements already present.
Stephanie F. Gaudreau, Tuan V. Bui
wiley +1 more source
A murine sinonasal infection model recapitulates key features of clinical chronic rhinosinusitis. [PDF]
J Med MicrobiolVanderpool EJ, Rumbaugh KP.
europepmc +1 more source
International Journal of Cancer, Volume 159, Issue 6, Page 1521-1534, 15 September 2026.Clinical trials of chimeric antigen receptor T‐cell (CAR‐T) therapies in glioblastoma have shown limited clinical benefits. Whether this may be explained by the basal quality of CAR‐T products, which are currently generated using patient, autologous T‐cells, has been little explored.
Sabra K. Salim +22 more
wiley +1 more source
Case Report and literature review: X-linked severe combined immunodeficiency complicated by <i>Talaromyces marneffei</i> infection caused by a novel pathogenic <i>IL2RG</i> mutation. [PDF]
Front PediatrQing D, Lin L, Chen F, Peng J.
europepmc +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 6, Page 406-419, September 2026.ABSTRACT Women with the FMR1 premutation (PM) are at increased risk for fragile X‐associated conditions (FXPAC), including cognitive and psychiatric features collectively termed fragile X‐associated neuropsychiatric disorders (FXAND). This study is the first to systematically investigate cognitive and psychiatric features in Italian female premutation ...
Federica Alice Maria Montanaro +5 more
wiley +1 more source
Optimizing human FcRn mouse models to improve pharmacokinetic evaluation of antibody drug candidates. [PDF]
MAbsChristianson G +6 more
europepmc +1 more source
Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Fatemeh Sabet Sarvestani +4 more
wiley +1 more source