Results 181 to 190 of about 196,305 (346)

Making Advanced Therapies Affordable and Accessible: Two Strategic Approaches

Developing World Bioethics, EarlyView.
ABSTRACT This article explores two complementary strategies for addressing the affordability and access challenges facing advanced therapies. As high development costs and limited market access have led to the withdrawal of several therapies, the article examines how these barriers create ‘valleys of death’ that prevent innovation from reaching ...
Ubaka Ogbogu, Lauren Albrecht
wiley   +1 more source

Gene therapy for B-cell lymphoma in a SCID mouse model using an immunoglobulin-regulated diphtheria toxin gene delivered by a novel adenovirus-polylysine conjugate [PDF]

, 1994
Cook, Deborah R., Curiel, David T., Curiel, Tyler J., Glode, L. M., Maxwell, F., Maxwell, I. H., Purner, M. B., Stevens, J. O., Wagner, Ernst   +8 more
core   +1 more source

Intervention timing and disease stage shape tecovirimat and cidofovir efficacy in male SCID mice. [PDF]

Nat Commun
Cao X, Shi N, Qiu X, Tian J, Wang P, Liu B, Ha Z, Zhang H, Shang C, Li X, Xie Y, Shu Y, Lu H.   +12 more
europepmc   +1 more source

SCID mice containing muscle with human mitochondrial DNA mutations. An animal model for mitochondrial DNA defects. [PDF]

, 1998
Kimberly Clark, Diana J. Watt, R.N. Lightowlers, Mark A. Johnson, João B. Relvas, Jan‐Willem Taanman, Douglass M. Turnbull   +6 more
openalex   +1 more source

Systematic Review and Meta‐Analysis of Mortality in Patients With Anorexia Nervosa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) has one of the highest mortality rates among psychiatric disorders. This systematic review and meta‐analysis examined the all‐cause mortality of AN patients compared to the general population using the standardized mortality ratio (SMR).
Eric Tsz‐Him Lai, Benjamin Lai, Corine Sau‐Man Wong, Lai‐Yi Wong, Kin‐Shing Cheng, Pak‐Wing Calvin Cheng, Lo Heidi Ka‐Ying, Gary Tse, Wai‐Chi Chan, Wing‐Chung Chang, Ka‐Fai Chung   +10 more
wiley   +1 more source

Negative and Positive Body‐Related Emotions Derived From Voice Recordings During a Mirror Task in Anorexia and Bulimia Nervosa: A Natural Language Processing Approach Using RoBERTa

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Body dissatisfaction has been linked to negative and positive emotions. The validity of self‐report methods to assess emotions in individuals with eating disorders is limited, prompting a shift towards methods like natural language processing to analyze speech content.
Linda Marie Sadowski, Christopher Lalk, Vanessa Hofschröer, Fanny Alexandra Dietel, Julia Tanck, Julian A. Rubel, Andrea S. Hartmann, Silja Vocks   +7 more
wiley   +1 more source

Mucosal B Cell Expansion and Maturation Contribute to Colitis Pathogenesis. [PDF]

Inflamm Bowel Dis
Fung ICN, Koelink PJ, Mulders LGM, Admiraal I, Verseijden C, Verhoeff J, Wildenberg ME, Luo Y, D'Haens GR, Li Yim AYF, de Jonge WJ.   +10 more
europepmc   +1 more source

On the SCIDs? [PDF]

Nature, 1989
D E, Mosier, R J, Gulizia, S M, Baird, D B, Wilson   +3 more
openaire   +2 more sources

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Implementation Timeframes for the Addition of New Conditions to Newborn Bloodspot Screening Programmes: A Scoping Review. [PDF]

Int J Neonatal Screen
Brennan MM, O'Connell A, O'Grady L, Elsammak M, Brady JJ, Marsden P, Burns H, Collins A.   +7 more
europepmc   +1 more source