Results 61 to 70 of about 1,478,138 (262)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Research Into STS Science Education
Educación Química, 2018 STS science curriculum content includes both the internal workings of the scientific enterprise and the scientific enterprises external interaction with technology and society.
Glen Aikenhead
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
SCIENCE EFFICIENCY IN HIGHER EDUCATION
Вестник Северо-Кавказского федерального университета, 2022 For the first time, the article proposes a method for assessing the scientific effectiveness of state institutions of higher education "Science-Efficiency".
D. Segal
doaj
Analogical Modelling in Science Education
Investigações em Ensino de Ciências, 2018 In this paper, we aimed at investigating: (i) the steps that can be used to guide the elaboration and the conduction of analogical modelling activities in science education; and (ii) the way in which the analogical modelling activities based on those ...
Nilmara Braga Mozzer +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Teacher Education: Science or Art? [PDF]
İnönü Üniversitesi Eğitim Fakültesi Dergisi, 2009 While being a teacher-educator is a complex task, the mode to train teacher-educators is yet unclear. This question is even more relevant because education colleges thriving for academic accreditation recruit PhDs with no field experience.
Mira KARNIELI
doaj
Modeling competence in science education
Disciplinary and Interdisciplinary Science Education Research, 2019 Research on the understanding of the nature of models and modeling processes in science education have received a lot of attention in science education.
Mei-Hung Chiu, Jing-Wen Lin
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source