Results 61 to 70 of about 564,241 (314)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

El Trabajo Social y los Campos Disciplinarios de las Ciencias Sociales en Chile [PDF]

open access: yes, 2012
The paper aims to review critically the concept of discipline and observe from it the classifications have been proposed to organize the subfields belonging to social sciences in Chile.
Farías, Fernando
core   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Un amour non partagé

open access: yesRevue d'anthropologie des connaissances, 2017
Les relations entre sciences sociales et études sociales des sciences et technologies (STS) sont fort complexes. Alors que, pour certains auteurs, l’inclusion des STS dans les sciences sociales est objet de disputes, d’autres ont tenté d’intéresser ...
Pablo Kreimer
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Les SHS à la croisée des chemins

open access: yesRevue Internationale d’Éducation de Sèvres, 2008
Les sciences humaines et sociales et l’avenir de leur enseignement sont régulièrement le sujet de débats passionnés et contradictoires. On s’interroge sur leur utilité sociale, on prédit leur fin prochaine, alors même que les universitaires de ces ...
Michel Lussault
doaj   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

open access: yesFEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart   +4 more
wiley   +1 more source

De l’intellectuel à l’expert

open access: yesRevue Internationale d’Éducation de Sèvres, 2008
As in many African countries, the university scene in Kenya has undergone profound changes during the past 20 years. The liberalisation of the availability of higher education has generated unprecedented forms of competition between courses and public ...
Hélène Charton, Samuel Owuor
doaj   +1 more source

Gestion à long terme des déchets nucléaires belges moyennement et hautement radioactifs: Construire un dispositif communicationnel mais comment? [PDF]

open access: yes, 2013
Aujourd’hui, personne ne remet plus en cause l’intégration d’une approche participative dans le processus de gestion des déchets moyennement et hautement radioactifs belges (de catégorie B&C).
Parotte, Céline
core  

Home - About - Disclaimer - Privacy