Results 121 to 130 of about 3,852,365 (305)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Religion and Which Sciences? Science and Which Community? [PDF]

, 2012
The author addresses ways in which participants in the religion-and-science dialogues avoid ethically sensitive issues involving the scientifically developed subject of nonhuman animals.
Waldau, Paul
core   +1 more source

‘Just as a scientific hypothesis’. The literary language of madness in Charlotte Perkins Gilman’s ‘The Yellow Wallpaper’

Odisea, 2017
: The focus of this article will be Charlotte Perkins Gilman’s thoroughly anthologized story ‘The Yellow Wallpaper’ (1892). Beyond the patriarchal perception of the narrator as progressively falling into madness, this study aims to prove that, in line ...
Gerardo Rodríguez Salas
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Incorrect arguments of scientific discourse in pedagogical texts, or samples for non-imitation

Образование и наука
Introduction. Modern humanities are moving towards compliance with the requirement of evidence and comprehensive validity of their conclusions, the adequacy of the methods used and re­search strategies to the results obtained. This problem can be briefly
A. V. Korzhuev, N. V. Golovina, N. A. Kontarov, Yu. B. Ikrennikova   +3 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Imagining 'environment' in sustainable development [PDF]

, 2010
The paper presents an argument for a broader and more complex definition of environment than that currently offered in sustainable development discourse and practice.
Farrelly, Trisia Angela
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Affective values of specialized discourse scientific discourse

, 2022
We are dangerous when we don#39;t understand the responsibility we have for how we act, feel and think, says Marshall Bertram Rosenberg, American psychologist, mediator, author and professor. In fact, each person bears a particular responsibility for what they say, influenced or not, by the mood they are in at the time.
Lopatiuc, A.V., Chiriac, A.A., Кирияк, А.A., Driga, I.   +3 more
openaire   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source