Results 91 to 100 of about 22,383,729 (330)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Pharmacogenetic testing in the treatment of type 2 diabetes with sulfonylurea drugs

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article analyses scientific literature on the use of pharmacogenetic testing to optimize sulfonylurea treatment of patients with type 2 diabetes.
G. I. Gorodetskaya, V. G. Kukes, S. A. Belkov, R. E. Kazakov, S. Yu. Serebrova, O. V. Muslimova, T. A. Rodina, A. A. Aleksandrov   +7 more
doaj  

EPOXI Mission: Comet on a Stick [PDF]

, 2009
In this activity, students examine their concepts of a comet by designing and building a model. The goal is to have students replicate the scientific processes of observing, modeling, forming an explanation, making new observations, and revising. In this
John Risvey
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Ketoacidosis as unexpected adverse reaction SGLT₂ inhibitor

Безопасность и риск фармакотерапии, 2018
Inhibitors of the sodium-glucose cotransporter-2 SGLT2 is a new class of hypoglycemic drugs. This article presents the information on FDA reports (2013-2015) and AIS (May 2015 - February 2016) on the risk of new adverse reaction - ketoacidosis ...
T. M. Bukatina, A. S. Kazakov, N. Yu. Velts, M. A. Darmostukova, K. E. Zatolochina, R. N. Alyautdin, V. P. Dobrynin, B. K. Romanov   +7 more
doaj  

Evaluating Scientific Impact [PDF]

Environmental Health Perspectives, 2000
B A, Van Houten, J, Phelps, M, Barnes, W A, Suk   +3 more
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Cell cultures in replacement therapy

Биопрепараты: Профилактика, диагностика, лечение, 2018
Cell replacement therapy is one of the top priority areas of modern medicine, which is aimed at restoring the structure and functions of damaged tissues by transplanting cells grown in vitro .
E. M. Petruchuk, N. V. Shalunova, Yu. V. Olefir, I. V. Borisevich, V. V. Perekrest, V. A. Shevtsov, A. V. Rukavishnikov, L. M. Khantimirova   +7 more
doaj  

2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

HYPERTENSION, 2018
Since 1980, the American College of Cardiology (ACC) and American Heart Association (AHA) have translated scientific evidence into clinical practice guidelines (guidelines) with recommendations to improve cardiovascular health.
P. Whelton, R. Carey, W. Aronow, D. Casey, Karen J Collins, Cheryl Dennison Himmelfarb, Sondra M. DePalma, S. Gidding, K. Jamerson, Daniel W. Jones, E. MacLaughlin, P. Muntner, B. Ovbiagele, Sidney C. Smith, Crystal C. Spencer, R. Stafford, S. Taler, Randal J. Thomas, K. Williams, J. Williamson, J. Wright   +20 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source