Results 101 to 110 of about 22,383,729 (330)

First available biosimilar monoclonal antibodies

Биопрепараты: Профилактика, диагностика, лечение, 2018
The review deals with the issues related to the special aspects of the development of the first available similar biopharmaceuticals/biological analogues («biosimilars») based on monoclonal antibodies.
Zh. I. Avdeeva, A. A. Soldatov, N. A. Alpatova, V. P. Bondarev, Yu. V. Olefir, V. A. Merkulov, V. D. Mosyagin, N. V. Medunitsyn   +7 more
doaj  

Scientific Evaluation of Charles Dickens^∗ [PDF]

Journal of Quantitative Linguistics, 2013
I report the results of the test, where the takers had to tell the prose of Charles Dickens from that of Edward Bulwer-Lytton, who is considered by many to be the worst writer in history of letters. The average score is about 50%, which is on the level of random guessing. This suggests that the quality of Dickens' prose is the same as of that of Bulwer-
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Contemplation of the possibility of extending the shelf life of human immunoglobulin reference standard used for determination of anticomplementary activity

Биопрепараты: Профилактика, диагностика, лечение, 2018
The article gives an account of the stability study performed for two batches of human immunoglobulin reference standard (RS) used for determination of anticomplementary activity (industry reference standard, IRS 42-28-430).
O. G. Kornilova, M. A. Krivykh, E. A. Husnatdinova, E. S. Konovalova, R. A. Volkova, O. V. Fadeykina, E. Yu. Kudasheva, A. A. Movsesyants   +7 more
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Scientific Realism without the Wave-Function: An Example of Naturalized Quantum Metaphysics [PDF]

, 2019
Scientific realism is the view that our best scientific theories can be regarded as (approximately) true. This is connected with the view that science, physics in particular, and metaphysics could (and should) inform one another: on the one hand, science
Allori, Valia
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Determination of visible particles in parenteral dosage forms and ophthalmic dosage forms

Регуляторные исследования и экспертиза лекарственных средств, 2018
The present article describes the approaches to the choice of methods for assessing the content of visible particles in parenteral and ophthalmic dosage forms, recognized in general pharmacopoeia monograph «Visible particles in parenteral dosage forms ...
Yu. V. Olefir, T. N. Bokovikova, L. A. Stronova, E. P. Gernikova, L. I. Mitkina, S. A. Manaeva, Yu. B. Purim, A. V. Pichugin   +7 more
doaj  

Scientific considerations for the regulatory evaluation of cell therapy products.

Biologicals (Print), 2017
Cell therapy involves the administration of a viable somatic cell preparation to a patient for the treatment of a disease or traumatic damage. Because cell therapies are complex and very different from traditional biological products, they present ...
J. Petricciani, T. Hayakawa, G. Stacey, J. Trouvin, I. Knezevic   +4 more
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Substantiation of conditions for determination of related substances in bisoprolol fumarate by HPLC

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article summarizes the results of information analysis of bisoprolol fumarate synthesis methods which differ in the number of stages and in raw materials used, and are associated with the major identified impurities A, E and G, according to the ...
O. A. Baturina, E. V. Chaykovskaya, E. P. Gernikova, T. N. Bokovikova, L. A. Stronova, Yu. R. Biglova, S. A. Manaeva, E. S. Tolmacheva   +7 more
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