Results 111 to 120 of about 17,660,936 (332)

Ketoacidosis as unexpected adverse reaction SGLT₂ inhibitor

Безопасность и риск фармакотерапии, 2018
Inhibitors of the sodium-glucose cotransporter-2 SGLT2 is a new class of hypoglycemic drugs. This article presents the information on FDA reports (2013-2015) and AIS (May 2015 - February 2016) on the risk of new adverse reaction - ketoacidosis ...
T. M. Bukatina, A. S. Kazakov, N. Yu. Velts, M. A. Darmostukova, K. E. Zatolochina, R. N. Alyautdin, V. P. Dobrynin, B. K. Romanov   +7 more
doaj  

The Nightscout system – description of the system and its evaluation in scientific publications [PDF]

, 2020
Oskar Kublin, Mariusz Stȩpień
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Cell cultures in replacement therapy

Биопрепараты: Профилактика, диагностика, лечение, 2018
Cell replacement therapy is one of the top priority areas of modern medicine, which is aimed at restoring the structure and functions of damaged tissues by transplanting cells grown in vitro .
E. M. Petruchuk, N. V. Shalunova, Yu. V. Olefir, I. V. Borisevich, V. V. Perekrest, V. A. Shevtsov, A. V. Rukavishnikov, L. M. Khantimirova   +7 more
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[Advertising or information in ophthalmology? : Scientific evaluation of a YouTube sample]. [PDF]

Ophthalmologe, 2021
Schrenk K, Khoramnia R, Feltgen N, Bachmann W, Ziemssen F, Rohrbach JM, Dimopoulos S.   +6 more
europepmc   +1 more source

How to Evaluate and Interpret a Scientific Article About Therapy Or Therapeutic Procedures? [PDF]

, 2017
Támara Otzen, Carlos Manterola, Maricela García-Domínguez   +2 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

First available biosimilar monoclonal antibodies

Биопрепараты: Профилактика, диагностика, лечение, 2018
The review deals with the issues related to the special aspects of the development of the first available similar biopharmaceuticals/biological analogues («biosimilars») based on monoclonal antibodies.
Zh. I. Avdeeva, A. A. Soldatov, N. A. Alpatova, V. P. Bondarev, Yu. V. Olefir, V. A. Merkulov, V. D. Mosyagin, N. V. Medunitsyn   +7 more
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Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Contemplation of the possibility of extending the shelf life of human immunoglobulin reference standard used for determination of anticomplementary activity

Биопрепараты: Профилактика, диагностика, лечение, 2018
The article gives an account of the stability study performed for two batches of human immunoglobulin reference standard (RS) used for determination of anticomplementary activity (industry reference standard, IRS 42-28-430).
O. G. Kornilova, M. A. Krivykh, E. A. Husnatdinova, E. S. Konovalova, R. A. Volkova, O. V. Fadeykina, E. Yu. Kudasheva, A. A. Movsesyants   +7 more
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