Results 121 to 130 of about 17,660,936 (332)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Methodological approaches to the choice of identification test methods for medicines

Регуляторные исследования и экспертиза лекарственных средств, 2018
The article summarises the main selective and non-selective methods of physical, chemical and physico-chemical analysis which are used in medicines identification testing and which differ in selectivity, sensitivity, informative value, sample preparation,
A. I. Lutseva, T. N. Bokovikova, V. A. Yashkir, L. A. Stronova, N. E. Kuzmina, M. V. Agapkina, L. I. Panova, E. N. Popova, N. V. Gadasina, L. N. Bulanova, V. I. Prokofieva   +10 more
doaj  

Scientific Workflow Interoperability Evaluation

, 2013
{"references": ["The National Science Foundation. Linked environments for\natmospheric discovery (lead), 2003. Available at: URL\nhttp://www.renci.org/focus-areas/project-archive/lead.", "Scott Koranda. Ligo inspiral analysis workflow, 2007. Available at:\nURL https://spaces.internet2.edu/display/scischworkflow/Home.", "Philip Maechling.
openaire   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Design of Scientific Research Performance Evaluation System in Application-oriented Universities Based on Balanced Scorecard [PDF]

, 2017
Wan Wang, Yinzhong Yang, Shaoyi Bei, Jianwen Wang   +3 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Certification of the industry reference standard for the specific activity of «BiVac polio» - live attenuated bivalent oral polio vaccine type 1 and 3

Биопрепараты: Профилактика, диагностика, лечение, 2018
The standardization and control of «BiVac polio» (live attenuated bivalent oral polio vaccine type 1 and 3) developed by M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides of the Russian Academy of Medical Sciences, called for ...
E. V. Karpova, A. D. Sangadzhieva, T. V. Mamontova, O. V. Fadeykina, R. A. Volkova, K. A. Sarkisyan, A. A. Movsesyants   +6 more
doaj  

The scientific considerations to evaluate the nutritional and health functional value of bibimbap [PDF]

Jung Eun Park, Youn‐Soo Cha
openalex   +1 more source

THE EVALUATION OF SCIENTIFIC PRODUCTION: SEARCH FOR ORIGINALITY OR SIMPLE COPYING [PDF]

, 2009
Vincentas Lamanauskas
openalex   +1 more source