Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The development of microbiological methods for drug analysis
Регуляторные исследования и экспертиза лекарственных средств, 2018 The article presents the review of the national regulatory documents on drug testing for microbiological characteristics, such as «Sterility», «Microbiological Purity» etc.
O. V. Gunar +6 more
doaj
Breast Reconstruction: Necessity for Further Standardization of the Current Surgical Techniques Attempting to Facilitate Scientific Evaluation and Select Tailored Individualized Procedures Optimizing Patient Satisfaction. [PDF]
Breast Care (Basel), 2021 Tampaki EC, Tampakis A.
europepmc +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Modern biological/biotechnological medicinal products. Topical issues and prospects for development
Биопрепараты: Профилактика, диагностика, лечение, 2018 The review provides with the information, related to the development, research and registration of new biological preparations, including the issues of terminology and classification.
Yu. V. Olefir +6 more
doaj
[Advertising or information in ophthalmology? : Scientific evaluation of a YouTube sample]. [PDF]
Ophthalmologe, 2021 Schrenk K +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Evaluation of advanced R and D topics in photovoltaics [PDF]
An evaluation of advanced research and development topics in photovoltaic that is summarized. The intent was to develop priorities in a list of advanced research and development activities.
Surek, T.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Ensuring Professionalism of the External Evaluation Commission: The Slovenian Case Study [PDF]
In 2006–2007, the Slovenian higher education (HE) system took the first steps toward building a national model of institutional external evaluation (IEE), which would be comparable with other European models. In the first part of the article, the authors
Karmen Rodman, Nada Trunk Sirca
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