Results 81 to 90 of about 4,066,029 (306)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Fruits of Intellectual Production Economic and Scientific Specialisation Among OECD Countries [PDF]

This paper brings together data from 14 OECD countries on scientific publications, patents and production specialisation to explore the relationship between economic and production specialisation for 17 manufacturing sectors. Since Marx, there has been a
Ammon Salter, Keld Laursen
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The Status of Queen Conch, Strombus gigas, Research in the Caribbean [PDF]

, 1997
Today there are approximately 230 published scientific papers on queen conch, Strombus gigas. Publication on this species began in the 1960's and increased rapidly during the 1980's and 1990's (Fig. 1).
Stoner, Allan W.
core  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Co-Cultivation of Komagataeibacter xylinus MS2530 with Various Yeast Strains: Production and characterization of bacterial cellulose Films

Carbohydrate Polymer Technologies and Applications
High production costs and low yield of bacterial cellulose (BC) remain major impediments to the large-scale industrial production of BC. Therefore, the cost reduction through utilization of inexpensive cultivation media, such as recycled industrial waste,
Marina Paronyan, Lusine Saghatelyan, Sona Avetisyan, Haykanush Koloyan, Marina Kinosyan, Valeri Bagiyan, Susanna Hovhannisyan, Olga Akopian, Anichka Hovsepyan   +8 more
doaj   +1 more source

Cross-over, thresholds, and interactions between science and technology: a tentative simplified model and initial notes about statistics from 120 countries [PDF]

The hypothesis of this paper is the existence of thresholds of scientific production that must be overcome to trigger new channels of interactions between the scientific and technological infrastructure.
Américo Tristão Bernardes, Eduardo da Motta e Albuquerque   +1 more
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Validation of the method for determination of prekallikrein activator in Human Albumin

Биопрепараты: Профилактика, диагностика, лечение, 2018
Prekallikrein activator (PKA) is regarded as one of the most important factors determining the safety of blood products such as albumin and intravenous immunoglobulin.
M. V. Tomilin, E. V. Filatova, M. M. Kuznetsova, V. V. Sudakova, N. V. Zubkova   +4 more
doaj  

Radiation hardness qualification of PbWO_4 scintillation crystals for the CMS Electromagnetic Calorimeter [PDF]

, 2010
Ensuring the radiation hardness of PbWO_4 crystals was one of the main priorities during the construction of the electromagnetic calorimeter of the CMS experiment at CERN.
Bornheim, A., Gataullin, M., Litvine, V., Ma, Y., Newman, H. B., Orimoto, T., Rogan, C., Timciuk, V., Veverka, J., Yang, Y., Zhang, L. Y., Zhu, K., Zhu, R. Y.   +12 more
core