Results 121 to 130 of about 22,645,468 (334)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Tensions et coordinations entre les acteurs des sciences de la performance sportive

open access: yesSociologies, 2012
This article is based on a study which examines how knowledge is produced in the field of sports performance, looking at the modes of coordination between researchers and the coaches with whom they collaborate.
Matthieu Delalandre
doaj  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

SciPub–019–Getting Your Article Published in Scientific Journals- an Event Report

open access: yesJournal of Multidisciplinary Healthcare, 2020
Nisha Jha, 1 Ranish Shrestha, 2 Sunil Shrestha, 3 Shital Bhandary, 4 Anil Khadka, 5 Pathyil Ravi Shankar 6 1Department of Pharmacology, KIST Medical College, Gwarko, Lalitpur, Nepal; 2Infection Control Unit, Nepal Cancer Hospital and Research Center ...
Jha N   +5 more
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Active scientific research management model and optimization decision mechanism based on big data

open access: yes大数据, 2019
During the scientific research management,a large number of data could be accessed from researchers,projects,output and other multi-dimensional.The big data of scientific research management implicitly contains tremendous highlyinterconnected knowledge ...
Ruili LUO, Yuanzhuo WANG
doaj  

The critical steps for successful research: The research proposal and scientific writing

open access: green, 2013
Pitchai Balakumar   +2 more
openalex   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

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