Results 101 to 110 of about 3,513,282 (267)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Analysis on Articles Published in Nursing Periodicals the Projects That Received Fund Subsidizing
Huli yanjiu, 2002 To understand the status quo of the nursing science research, articles had published in core nursing periodicals including "Chinese Journal of Nursing", "Journal of Nurses Training","Chinese Nursing Research",and"Journal of Practical Nursing" from 1999 ...
李亚琴, 程金莲, 刘雪萍
doaj
SciPub–019–Getting Your Article Published in Scientific Journals- an Event Report
Journal of Multidisciplinary Healthcare, 2020 Nisha Jha, 1 Ranish Shrestha, 2 Sunil Shrestha, 3 Shital Bhandary, 4 Anil Khadka, 5 Pathyil Ravi Shankar 6 1Department of Pharmacology, KIST Medical College, Gwarko, Lalitpur, Nepal; 2Infection Control Unit, Nepal Cancer Hospital and Research Center ...
Jha N +5 more
doaj
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach
FEBS Letters, EarlyView.The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring +3 more
wiley +1 more source
DiversityThe National Museum of Natural History and Science holds a historical collection of 279 small African mammal specimens (Macroscelidea and Rodentia), representing 32 species, gathered during the Portuguese colonial period in Mozambique, Angola, and Guinea-
Maria da Luz Mathias, Rita I. Monarca
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source