Results 91 to 100 of about 20,856,203 (292)

Public Preferences about Fairness and the Ethics of Allocating Scarce Medical Interventions [PDF]

, 2017
This chapter examines how social- scientific research on public preferences bears on the ethical question of how those resources should in fact be allocated, and explain how social-scientific researchers might find an understanding of work in ethics ...
Persad, Govind
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

THE MEANINGS, PURPOSE AND FUNCTION OF THE CONTEMPORARY RUSSIAN GRADUATE SCHOOL: PROBLEM ANALYSIS

Вестник Северо-Кавказского федерального университета, 2022
The article deals with various aspects of understanding of the modern model of the Russian postgraduate school as a level of higher education. The scientific, normative, statistical materials and data revealing the target and functional basis of ...
Sergey Bobryshov, Natalia Dzhegutanova
doaj  

Criteria for the successful completion of medical dissertations - A multicenter study [Kriterien für den erfolgreichen Abschluss medizinischer Dissertationen – eine multizentrische Studie]

GMS Zeitschrift für Medizinische Ausbildung, 2010
[english] Objective: In order to acquire the academic title “doctor” in Germany, it is essential to complete a dissertation. A high number of publications at German universities are based on medical dissertations.
Harendza, Sigrid, Jüptner, Markus, Biegler, Astrid, Böthern, Aenne M., Reissner, Volker, Kuhnigk, Olaf, Schäfer, Ingo   +6 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Long-term effects of on-the-job skills (mis)match on employee wellbeing and employability: a 7-wave longitudinal study

Frontiers in Psychology
On-the-job skills match, in which employee knowledge and proficiencies (skills) are well-matched with the needs of the job, is often considered more beneficial, both for employees as well as for organizations and society, than a mismatch.
Linda Koopmans, Marieke van den Tooren, Paul Preenen, Paul Preenen   +3 more
doaj   +1 more source

Tosio Kato's Work on Non-Relativistic Quantum Mechanics: An Outline [PDF]

, 2017
Based at a talk given at the Kato Centennial Symposium in Sept. 2017, this article discusses the scientific life and some of the scientific work of T. Kato.Comment: 15 pages.
Simon, Barry
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

MORAL RIGHTS IN THE CASE OF DOCTORAL THESES. LIMITATIONS OF MORAL RIGHTS [PDF]

Challenges of the Knowledge Society
This study attempts an analysis of the doctoral thesis from the perspective of copyright, specifically examining the prerogatives and limitations of copyright when a doctoral thesis is created.
Ionuț Cătălin TIRITEU
doaj  

Identifying patient subgroups in MASLD and MASH-associated fibrosis: molecular profiles and implications for drug development

Scientific Reports
The incidence of MASLD and MASH-associated fibrosis is rapidly increasing worldwide. Drug therapy is hampered by large patient variability and partial representation of human MASH fibrosis in preclinical models.
Manuel A. González Hernández, Lars Verschuren, Martien P.M. Caspers, Martine C. Morrison, Jennifer Venhorst, Jelle T. van den Berg, Beatrice Coornaert, Roeland Hanemaaijer, Gerard J. P. van Westen   +8 more
doaj   +1 more source