Results 131 to 140 of about 3,068,645 (312)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Opinion: Authors overestimate their contribution to scientific work, demonstrating a strong bias. [PDF]
Proc Natl Acad Sci U S A, 2020 Herz N, Dan O, Censor N, Bar-Haim Y.
europepmc +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Between fetishism and survival : is the scientific article an academic commodity? [PDF]
, 2007 This article discusses the possible meanings of the intense prevailing concern in academic circles over the notion of research productivity, as reflected in an excess number of articles published in various scientific journals.
Sanz-Valero, Javier, Castiel, Luis D.
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Social work as narrative: An investigation of the social and literary nature of social work accounting [PDF]
, 1993 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis investigates what can be gained by approaching social work reports and conversations as narratives.
Hall, Christopher J, Hall, C.J
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The Making of Scientific Knowledge [PDF]
What does really happen between the moment when a scientist is observing a bird in the wild and publishing a scientific chart? Jana Thierfelder reveals the hidden life of field science through the 30-year archive of biologist Michael Griesser’s work with
Thierfelder, Jana
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
STUDENTS’ PERCEPTION AND ATTITUDE TOWARDS SCIENTIFIC WORK DURING UNIVERSITY STUDIES [PDF]
Strengthening the scientific component within the structure of the educational process in modern higher educational institutions in Ukraine has determined the task of clarifying students’ perception of the essence of conducting scientific work.
Demydenko, Tetyana +3 more
core +2 more sources