Results 141 to 150 of about 20,856,203 (292)
Modelling and Simulation in EngineeringThis work treats a finite-element analysis of the oscillations in damaged pipeline sections reinforced with a composite wrap performed by ANSYS software when the thickness of the composite wrap was 2.0, 3.0, and 4.0 mm, while the length of the wrap was ...
Arman Moldagaliyev +6 more
doaj +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Swiss chocolate and free beverages to increase the motivation for scientific work amongst residents: a prospective interventional study in a non-academic teaching hospital in Switzerland. [PDF]
Trials, 2020 Rühle A +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Hypatia's silence. Truth, justification, and entitlement. [PDF]
Hartry Field distinguished two concepts of type-free truth: scientific truth and disquotational truth. We argue that scientific type-free truth cannot do justificatory work in the foundations of mathematics.
Fischer, Martin +2 more
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Journal of Business Economics and ManagementThis article presents Professor Joanicjusz Nazarko’s outstanding achievements in research, scientific cooperation, teaching and organizational work, in celebration of the 45th jubilee of his scientific work.
Martyna Wilczewska +2 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Jurnal Layanan Masyarakat (Journal of Public Services)Basic training in scientific journal writing techniques is an important activity for undergraduate students in understanding the structure of scientific work.
Bambang Suprianto, Suhendra suhendra
doaj +1 more source