Results 1 to 10 of about 80,483 (293)
Scleroderma with Nodular Scleroderma [PDF]
Case Reports in Dermatology, 2016 Background: Nodular scleroderma is a rare variant of scleroderma which can occur in connection with systemic sclerosis or morphea. A biopsy from the lesion can demonstrate the scleroderma pattern, i.e., keloid pattern or mixed type.
Chutika Srisuttiyakorn +1 more
doaj +4 more sources
Frontiers in Immunology, 2021 Microvascular injury is considered an initial event in the pathogenesis of scleroderma and endothelial cells are suspected of being the target of the autoimmune process seen in the disease. EBV has long been proposed as a trigger for autoimmune diseases,
Antonella Farina +2 more
exaly +3 more sources
Frontiers in Immunology, 2019 Systemic sclerosis is a profibrotic autoimmune disease mediated by the dysregulation of extracellular matrix synthesis. Formyl peptide receptor 2 (Fpr2) is a G protein-coupled receptor that modulates inflammation and host defense by regulating the ...
Gyu Tae Park, Tae Wook Lee
exaly +3 more sources
Scleroderma and scleroderma-like syndromes
Frontiers in ImmunologySystemic sclerosis is a systemic connective tissue disease whose main pathophysiological mechanism is a progressive fibrosis of internal organs and skin leading to thickening and induration. Blood vessels may also be involved.
Katarzyna Romanowska-Próchnicka +4 more
doaj +3 more sources
Infections of scleroderma digital ulcers: a single center cohort retrospective study
Dermatology Reports, 2021 BACKGROUNDS: Systemic Sclerosis (SSc) is a complex autoimmune and up to fifty percent of patients develop digital ulcers. AIMS: Understand how much infections influence scleroderma digital ulcers’ healing.
Dilia Giuggioli +7 more
doaj +1 more source
Pharmaceuticals, 2022 The role of Bronchoalveolar Lavage (BAL) in the evaluation of systemic sclerosis (SSc) interstitial lung disease (ILD) is still controversial. The aim of this systematic literature review was to investigate the use of BAL in SSc-ILD, and to focus on the ...
Martina Orlandi +8 more
doaj +1 more source
Correction to: Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis
Arthritis Research & Therapy, 2021 An amendment to this paper has been published and can be accessed via the original article.
David A. Fox +14 more
doaj +1 more source
Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis
Arthritis Research & Therapy, 2021 Background Abnormalities in lymphocyte surface markers and functions have been described in systemic sclerosis (SSc), but conflicting results abound, and these studies often examined patients with heterogeneous disease duration, severity, clinical ...
David A. Fox +14 more
doaj +1 more source
Scientific Reports, 2021 Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described.
Giuseppina Abignano +5 more
doaj +1 more source
Nature Communications, 2022 A20 gene variants are linked with systemic sclerosis (SS), but the mechanisms are unclear. Here, the authors show that A20 expression is reduced in SS skin and lungs, that its ablation in mice induces SS, and that show that fibrosis can be ameliorated by
Wenxia Wang +23 more
doaj +1 more source