Results 1 to 10 of about 80,018 (239)

Scleroderma with Nodular Scleroderma [PDF]

Case Reports in Dermatology, 2016
Background: Nodular scleroderma is a rare variant of scleroderma which can occur in connection with systemic sclerosis or morphea. A biopsy from the lesion can demonstrate the scleroderma pattern, i.e., keloid pattern or mixed type.
Chutika Srisuttiyakorn, Kobkul Aunhachoke   +1 more
doaj   +3 more sources

Scleroderma and scleroderma-like syndromes

Frontiers in Immunology
Systemic sclerosis is a systemic connective tissue disease whose main pathophysiological mechanism is a progressive fibrosis of internal organs and skin leading to thickening and induration. Blood vessels may also be involved.
Katarzyna Romanowska-Próchnicka, Martyna Dziewit, Aleksandra Lesiak, Adam Reich, Marzena Olesińska   +4 more
doaj   +3 more sources

Infections of scleroderma digital ulcers: a single center cohort retrospective study

Dermatology Reports, 2021
BACKGROUNDS: Systemic Sclerosis (SSc) is a complex autoimmune and up to fifty percent of patients develop digital ulcers. AIMS: Understand how much infections influence scleroderma digital ulcers’ healing.
Dilia Giuggioli, Luca Magnani, Amelia Spinella, Gianluigi Bajocchi, Adalgisa Palermo, Federica Lumetti, Emanuele Cocchiara, Carlo Salvarani   +7 more
doaj   +1 more source

The Role of Bronchoalveolar Lavage in Systemic Sclerosis Interstitial Lung Disease: A Systematic Literature Review

Pharmaceuticals, 2022
The role of Bronchoalveolar Lavage (BAL) in the evaluation of systemic sclerosis (SSc) interstitial lung disease (ILD) is still controversial. The aim of this systematic literature review was to investigate the use of BAL in SSc-ILD, and to focus on the ...
Martina Orlandi, Laura Antonia Meliante, Arianna Damiani, Lorenzo Tofani, Cosimo Bruni, Serena Guiducci, Marco Matucci-Cerinic, Silvia Bellando-Randone, Sara Tomassetti   +8 more
doaj   +1 more source

Correction to: Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis

Arthritis Research & Therapy, 2021
An amendment to this paper has been published and can be accessed via the original article.
David A. Fox, Steven K. Lundy, Michael L. Whitfield, Veronica Berrocal, Phillip Campbell, Stephanie Rasmussen, Ray Ohara, Alexander Stinson, Mikel Gurrea-Rubio, Evan Wiewiora, Catherine Spino, Erica Bush, Daniel Furst, Shiv Pillai, Dinesh Khanna   +14 more
doaj   +1 more source

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]

, 2015
In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Abraham, D, Ahmed-Abdi, B, Denton, C, Lafyatis, R, Layne, MD, Nikitorowicz-Buniak, J, Ponticos, M, Shiwen, X, Smith, BD, Stratton, R, Suki, B, Takahashi, A   +11 more
core   +7 more sources

Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis

Arthritis Research & Therapy, 2021
Background Abnormalities in lymphocyte surface markers and functions have been described in systemic sclerosis (SSc), but conflicting results abound, and these studies often examined patients with heterogeneous disease duration, severity, clinical ...
David A. Fox, Steven K. Lundy, Michael L. Whitfield, Veronica Berrocal, Phillip Campbell, Stephanie Rasmussen, Ray Ohara, Alexander Stinson, Mikel Gurrea-Rubio, Evan Wiewiora, Catherine Spino, Erica Bush, Daniel Furst, Shiv Pillai, Dinesh Khanna   +14 more
doaj   +1 more source

Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs

Nature Communications, 2022
A20 gene variants are linked with systemic sclerosis (SS), but the mechanisms are unclear. Here, the authors show that A20 expression is reduced in SS skin and lungs, that its ablation in mice induces SS, and that show that fibrosis can be ameliorated by
Wenxia Wang, Swarna Bale, Jun Wei, Bharath Yalavarthi, Dibyendu Bhattacharyya, Jing Jing Yan, Hiam Abdala-Valencia, Dan Xu, Hanshi Sun, Roberta G. Marangoni, Erica Herzog, Sergejs Berdnikovs, Stephen D. Miller, Amr H. Sawalha, Pei-Suen Tsou, Kentaro Awaji, Takashi Yamashita, Shinichi Sato, Yoshihide Asano, Chinnaswamy Tiruppathi, Anjana Yeldandi, Bettina C. Schock, Swati Bhattacharyya, John Varga   +23 more
doaj   +1 more source

Global gene expression analysis of systemic sclerosis myofibroblasts demonstrates a marked increase in the expression of multiple NBPF genes

Scientific Reports, 2021
Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described.
Giuseppina Abignano, Heidi Hermes, Sonsoles Piera-Velazquez, Sankar Addya, Francesco Del Galdo, Sergio A. Jimenez   +5 more
doaj   +1 more source

Early nurturing experiences, self-compassion, hyperarousal and scleroderma the way we relate to ourselves may determine disease progression [PDF]

, 2016
<p>Scleroderma is a rare, painful and complex autoimmune connective tissue disease that can lead to death. The physiology of symptom onset and progression and the psychological aspects of living with this chronic disease have been studied fairly ...
Hicks, Richard E., Kearney, Karen
core   +1 more source