Results 11 to 20 of about 1,415,478 (254)

Immunopathogenesis of Pediatric Localized Scleroderma [PDF]

Frontiers in Immunology, 2019
Localized scleroderma (LS) is a complex disease characterized by a mixture of inflammation and fibrosis of the skin that, especially in the pediatric population, also affects extracutaneous tissues ranging from muscle to the central nervous system. Although developmental origins have been hypothesized, evidence points to LS as a systemic autoimmune ...
Kathryn S. Torok, Suzanne C. Li, Suzanne C. Li, Heidi M. Jacobe, Sarah F. Taber, Sarah F. Taber, Anne M. Stevens, Anne M. Stevens, Francesco Zulian, Theresa T. Lu, Theresa T. Lu, Theresa T. Lu   +11 more
doaj   +5 more sources

Barriers to care in juvenile localized and systemic scleroderma: an exploratory survey study of caregivers’ perspectives

Pediatric Rheumatology Online Journal, 2023
Background Juvenile localized scleroderma (LS) and systemic sclerosis (SSc) are rare pediatric conditions often associated with severe morbidities. Delays in diagnosis are common, increasing the risk for permanent damage and worse outcomes.
Leigh A. Stubbs, Andrew M. Ferry, Danielle Guffey, Christina Loccke, Erin Moriarty Wade, Pamela Pour, Kaveh Ardalan, Peter Chira, Ingrid M. Ganske, Daniel Glaser, Gloria Higgins, Nadia Luca, Katharine F. Moore, Vidya Sivaraman, Katie Stewart, Natalia Vasquez-Canizares, Raegan D. Hunt, Renata S. Maricevich, Kathryn S. Torok, Suzanne C. Li, Childhood Arthritis, Rheumatology Research Alliance (CARRA) Scleroderma Workgroup   +20 more
doaj   +2 more sources

Successful treatment of localized scleroderma using brodalumab: A case report [PDF]

SAGE Open Medical Case Reports
We report the first documented use of brodalumab, an IL-17 receptor antagonist, for treating severe linear localized scleroderma refractory to conventional therapies, including methotrexate, mycophenolate mofetil and corticosteroids.
Alexandra Carla Bobica, Catherine Zhu, Catherine Silotch, Hessah BinJadeed, Elena Netchiporouk   +4 more
doaj   +2 more sources

Case Report: Exacerbation after fat grafting in patients with active localized scleroderma [PDF]

Frontiers in Surgery
BackgroundThe application of autologous fat transplantation in facial lesions of patients with localized scleroderma (LoS) has been reported in recent years.ObjectiveThe authors report a case of worsening of active localized scleroderma after autologous ...
Shunxin Han, Juzi Liu, Feng Lu, Junrong Cai   +3 more
doaj   +2 more sources

Endpoints and outcomes for localized scleroderma/morphea: a scoping literature review [PDF]

Pediatric Rheumatology Online Journal
Background Current treatment for localized scleroderma (LS) has been shown to halt disease activity, but little is still known about patient experiences with these treatments, nor is there consensus about optimal measurement strategies for future ...
Alexy Hernandez, Leslie Zapata Leiva, Maria Mutka, Kathryn S. Torok, Leila Ledbetter, Christina K. Zigler   +5 more
doaj   +2 more sources

Mycophenolate mofetil for methotrexate-resistant juvenile localized scleroderma [PDF]

Rheumatology, 2021
Objectives: To investigate safety and efficacy of MMF in patients with severe or MTX-refractory juvenile localized scleroderma. Methods: Consecutive juvenile localized scleroderma patients undergoing systemic treatment were included in a retrospective ...
Culpo R., Martini G., Meneghel A., Saggioro L., Vittadello F., Zulian F.   +5 more
core   +2 more sources

Evaluation of Thiol Disulfide, Ischemia Modified Albumin, and Prolidase Parameters in Patients With Localized Scleroderma [PDF]

Dermatology Practical & Conceptual
Introduction: Localized scleroderma is a rare inflammatory skin disease that causes sclerosis in the dermis and subcutaneous tissue. Oxidative stress may play a role in the etiology or be responsible for the chronicity or progression of the disease ...
Ayşe Akbaş, Orhan Sen, Fadime Kılınç , Salim Neselioglu, Gülhan Aksoy Saraç, Akın Aktaş   +5 more
doaj   +2 more sources

Presentation and Outcomes of Localized Immunoglobulin Light Chain Amyloidosis: 14‐Year Experience of an Academic Center [PDF]

Hematological Oncology, Volume 43, Issue 3, May 2025.
ABSTRACT Localized light chain amyloidosis (loc‐AL) is a rare disorder characterized by localized deposition of misfolded AL fibrils. There are limited data on patterns of disease presentation and long‐term outcomes. In this study, we retrospectively reviewed 146 patients with loc‐AL at our institution between January 1, 2010, and March 1, 2024.
Danai Dima, Utkarsh Goel, Fauzia Ullah, Beth Faiman, Diana Basali, Sandra Mazzoni, Louis S. Williams, Christy Samaras, Jason Valent, Faiz Anwer, Jack Khouri, Shahzad Raza   +11 more
wiley   +2 more sources

Enhancing Hair Regrowth in Pediatric Morphea en Coup de Sabre by Fractional CO2 Laser‐Assisted Exosome Delivery [PDF]

J Cosmet Dermatol
Journal of Cosmetic Dermatology, Volume 24, Issue 6, June 2025.
Rhea Ahuja, Patrick Po‐Han Huang
wiley   +2 more sources

Single-Cell Transcriptome Analysis Identifies Subclusters with Inflammatory Fibroblast Responses in Localized Scleroderma

International Journal of Molecular Sciences, 2023
Localized scleroderma (LS) is an autoimmune disease with both inflammatory and fibrotic components causing an abnormal deposition of collagen in the skin and underlying tissue, often leading to disfigurement and disability. Much of its pathophysiology is
Giffin Werner, Anwesha Sanyal, E. Mirizio, Theresa Hutchins, T. Tabib, R. Lafyatis, Heidi Jacobe, K. Torok   +7 more
semanticscholar   +1 more source