Results 11 to 20 of about 1,472,132 (249)
Immunopathogenesis of Pediatric Localized Scleroderma
Frontiers in Immunology, 2019 Localized scleroderma (LS) is a complex disease characterized by a mixture of inflammation and fibrosis of the skin that, especially in the pediatric population, also affects extracutaneous tissues ranging from muscle to the central nervous system ...
Kathryn S. Torok +11 more
doaj +2 more sources
International Journal of Molecular Sciences, 2023 Localized scleroderma (LS) is an autoimmune disease with both inflammatory and fibrotic components causing an abnormal deposition of collagen in the skin and underlying tissue, often leading to disfigurement and disability. Much of its pathophysiology is
Giffin Werner +7 more
semanticscholar +1 more source
Pediatric Rheumatology Online Journal, 2023 Background Juvenile localized scleroderma (LS) and systemic sclerosis (SSc) are rare pediatric conditions often associated with severe morbidities. Delays in diagnosis are common, increasing the risk for permanent damage and worse outcomes.
L. Stubbs +19 more
semanticscholar +1 more source
Application of an iPSC‐Derived Organoid Model for Localized Scleroderma Therapy
Advancement of science, 2022 Localized scleroderma (LoS) is a rare chronic disease with extensive tissue fibrosis, inflammatory infiltration, microvascular alterations, and epidermal appendage lesions.
Jie Ma +16 more
semanticscholar +1 more source
Clinical, Cosmetic and Investigational Dermatology, 2022 Introduction Localized scleroderma, also known as Morphea, is a chronic inflammatory condition of connective tissue, the etiology of which is unknown. There is skin thickening with increased quantities of collagen in the indurative lesion. Skin hyperemia
Jaishree Sharad
semanticscholar +1 more source
Photodermatology, Photoimmunology & Photomedicine, 2022 Localized scleroderma (LS) is a rare disease leading to progressive hardening and induration of the skin and subcutaneous tissues. LS is responsive to UVA‐1 phototherapy, though its exact mechanism of action dermal fibrosis is yet to be fully elucidated.
L. Tognetti +6 more
semanticscholar +1 more source
Stem Cells Translational Medicine, 2021 In patients with localized scleroderma (LoS), facial deformity induced by subcutaneous atrophy greatly reduces life quality. Autologous fat grafting (AFG) is used for volume restoration but with low‐fat retention due to various reasons.
Chenyu Wang +8 more
semanticscholar +1 more source
Clinical periodontal diagnosis
Periodontology 2000, EarlyView., 2023 Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi +5 more
wiley +1 more source
Genetic Signatures From RNA Sequencing of Pediatric Localized Scleroderma Skin
Frontiers in Pediatrics, 2021 The purpose of this study was to explore the skin transcriptional profile in pediatric localized scleroderma (LS) to provide a better understanding of the altered immune and fibrotic pathways promoting disease. LS is a progressive disease of the skin and
E. Mirizio +9 more
semanticscholar +1 more source
The Anti-Fibrotic Effect of Cold Atmospheric Plasma on Localized Scleroderma In Vitro and In Vivo
Biomedicines, 2021 Cold Atmospheric Plasma (CAP) has shown promising results in the treatment of various skin diseases. The therapeutic effect of CAP on localized scleroderma (LS), however, has not yet been evaluated.
S. Arndt +4 more
semanticscholar +1 more source