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Modern methods of a localized scleroderma diagnostics [PDF]

Саратовский научно-медицинский журнал, 2016
Localized scleroderma (LS) is a disease that is characterized by the appearance of inflammatory, sclerotic and/or atrophic changes in the affected areas of the skin and underlying tissues.
Moiseyev А.А., Utz S.R.
doaj  

Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: A new potential target for antifibrotic therapy [PDF]

, 2018
Background: Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-BB) are profibrotic molecules ...
Berardicurti O., Carubbi F., Ciccia F., Cipriani P., Di Bartolomeo S., Di Benedetto P., Giacomelli R., Guggino G., Liakouli V., Panzera N., Ruscitti P., Triolo G.   +11 more
core   +1 more source

CLINICAL SIGNIFICANCE OF EXTRACORPOREAL PHOTOCHEMOTHERAPY IN COMPLEX TREATMENT OF LOCALIZED SCLERODERMA

Alʹmanah Kliničeskoj Mediciny, 2016
Background: Scleroderma is an autoimmune disease with progressing lesions of connective tissue where fibrosclerotic and vascular disturbances prevail.
O. A. Fomina, A. V. Molochkov, A. V. Kil’dyushevsky   +2 more
doaj   +1 more source

Quantitative nanohistological investigation of scleroderma: An atomic force microscopy-based approach to disease characterization [PDF]

, 2017
Scleroderma (or systemic sclerosis, SSc) is a disease caused by excess crosslinking of collagen. The skin stiffens and becomes painful, while internally, organ function can be compromised by the less elastic collagen.
Aguayo, S, Ahmed, T, Bozec, L, Mordan, N, Parekh, S, Porter, SR, Strange, AP, Stratton, R   +7 more
core   +1 more source

Update on Management of Morphea (Localized Scleroderma) in Children

Indian Dermatology Online Journal, 2020
Juvenile localized scleroderma (morphea) is the predominant scleroderma in childhood which affects the skin and may extend to the underlying fascia, muscle, joints and bone.
R. George, Anju George, T. Kumar
semanticscholar   +1 more source

Morphea profunda – a case report of deep localized scleroderma with severe thorax deformity

Annales Academiae Medicae Silesiensis
Deep scleroderma is a rare form of limited scleroderma characterised by deep sclerosis that may involve the muscles, fascia, subcutaneous tissue and deep layers of the skin.
Natalia Tekiela, Agnieszka Guberniak, Karina Polak, Bartosz Miziołek, Beata Bergler-Czop   +4 more
doaj   +1 more source

Adult-onset en coup de sabre scleroderma in a patient with linear localized scleroderma profunda: A case report and literature review

SAGE Open Medical Case Reports, 2021
The en coup de sabre variant of linear scleroderma typically occurs in children. We report a unique case of adult-onset en coup de sabre scleroderma in a patient with linear localized scleroderma profunda.
Roxana Mititelu, Zainab Ridha, Lydia Ouchene, Elena Netchiporouk   +3 more
doaj   +1 more source

Intramuscular Polydeoxyribonucleotides in Fibrotic and Atrophic Localized Scleroderma: An Explorative Prospective Cohort Study

Biomedicines, 2023
Effective options in the quiescent, scantily inflammatory phase of localized scleroderma (morphea) are lacking. A cohort study in patients with histologically confirmed fibroatrophic morphea explored the therapeutic value of the anti-dystrophic A2A ...
Maurizio Romagnuolo, Chiara Moltrasio, Angelo Valerio Marzano, Gianluca Nazzaro, Simona Muratori, Sebastiano Recalcati   +5 more
doaj   +1 more source

Recent Advances in Systemic Scleroderma in Childhood [PDF]

, 2015
Ann Paediatr Rheumatol Annals of paediatric rheumatolog http://www.aprjournal.org/ 2146-2909 ...
Constantin, Tamás, Györgyi, Zoltán, Ivan Foeldvari, Peter Weiser, Szabó, András   +4 more
core   +1 more source

Antinuclear Antibodies in Localized Scleroderma [PDF]

Arthritis & Rheumatism, 1983
AbstractWhen HeLa cells were used as the substrate for detection by the indirect immunofluorescence method, antinuclear antibodies were demonstrated in 16 of 22 (72.7%) sera from patients with localized scleroderma. When mouse kidney sections were used, the positive rate for antinuclear antibodies was 50% (11 of 22).
K, Takehara, Y, Moroi, Y, Nakabayashi, Y, Ishibashi   +3 more
openaire   +3 more sources