Results 151 to 160 of about 56,983 (273)

Systemic lupus erythematosus‐associated autoantibodies in sickle cell disease: Spontaneous emergence in a patient and in transgenic sickle mice

British Journal of Haematology, Volume 206, Issue 4, Page 1213-1217, April 2025.
Summary We describe a patient with sickle cell disease (SCD) and elevated antiphospholipid antibodies (aPL) who developed multi‐organ failure resembling catastrophic antiphospholipid syndrome. Autoimmune screening revealed several autoantibodies characteristic of systemic lupus erythematosus (SLE). Notably, routinely housed and unmanipulated transgenic
Urshita Sinha, Suman Setty, Céleste Pilon, Julia J. Brown, Maria Armila Ruiz, Guohui Ren, Joyce Rauch, Santosh L. Saraf, Jerrold S. Levine   +8 more
wiley   +1 more source

Systemic Sclerosis Presenting as Osteomyelitis of the Finger: Physicians Must Maintain a High Index of Suspicion for Systemic Sclerosis when Evaluating Patients with Fingertip Ulceration or Infection. [PDF]

J Orthop Case Rep
Poucke LV, Hinton JB, Heck HC, Heck BE, Heck BE.   +4 more
europepmc   +1 more source

Therapeutic targeting of TGF‐β in lung cancer

The FEBS Journal, Volume 292, Issue 7, Page 1520-1557, April 2025.
Here, we discuss how lung cancer treatment can be transformed by targeting TGF‐β for better outcomes. Inhibiting TGF‐β signaling halts tumor growth, boosts immune response, and enhances treatment efficacy. By tackling TGF‐β's role in epithelial–mesenchymal transition (EMT) and immune evasion, this approach opens new avenues for more effective lung ...
Sajjad Aftabi, Amir Barzegar Behrooz, Marco Cordani, Niloufar Rahiman, Mohammadamin Sadeghdoust, Farnaz Aligolighasemabadi, Stephen Pistorius, Seyedeh Hoda Alavizadeh, Nima Taefehshokr, Saeid Ghavami   +9 more
wiley   +1 more source

Incidence, prevalence, and mortality of localized scleroderma in Quebec, Canada: a population-based study. [PDF]

Lancet Reg Health Am
Ghazal S, Muntyanu A, Aw K, Kaouache M, Khoury L, Piram M, McCuaig C, Chédeville G, Rahme E, Osman M, Schachter J, Bertrand J, Netchiporouk E.   +12 more
europepmc   +1 more source

Assessing the Health Implications of UV/LED Nail Lamp Radiation Exposure During Manicure and Pedicure Procedures: A Scoping Review

International Journal of Dermatology, Volume 64, Issue 4, Page 659-666, April 2025.
ABSTRACT Skin malignancies associated with radiation exposure, notably malignant melanoma and keratinocyte carcinoma, are emerging as a significant global health challenge. While indoor tanning beds are associated with skin cancer risk, limited research exists on ultraviolet (UV)/light‐emitting diode (LED) nail lamps used widely in manicures/pedicures.
Dmitry Beylin, Rachel Kornhaber, Danielle Le Lagadec, Michelle Cleary   +3 more
wiley   +1 more source

A hybrid protein is a functional molecule to reduce the cytokine storm caused by excessively activated macrophages

Immunology &Cell Biology, Volume 103, Issue 4, Page 350-364, April 2025.
In this article, we have developed a hybrid protein, tentatively named human MIKO‐1 (hMIKO‐1). The messenger RNA expression of each proinflammatory cytokine was significantly suppressed by hMIKO‐1 despite a subsequent stimulation with lipopolysaccharide. hMIKO‐1 is a functional molecule that significantly attenuates the cytokine storm.
Masaki Ikemoto, Takuya Kotani, Kohki Okada, Shogo Matsuda, Tohru Takeuchi   +4 more
wiley   +1 more source

The minimal clinically important difference of the scleroderma clinical trials consortium damage index. [PDF]

J Scleroderma Relat Disord
Baron M, Hansen D, Proudman S, Stevens W, Wang M, Nikpour M.   +5 more
europepmc   +1 more source

In Silico–Designed TGFβRI/TGFβRII Receptor Complex Peptide Inhibitors Exhibit Biological Activity In Vitro

Journal of Cellular and Molecular Medicine, Volume 29, Issue 8, April 2025.
ABSTRACT TGF‐β (transforming growth factor β) is a pleiotropic cytokine found in three isoforms in humans. It regulates cell proliferation, wound healing, immune cell recruitment, contributes to epithelial‐to‐mesenchymal transition (EMT) and to the conversion of fibroblasts to myofibroblasts.
Jacek Plichta, Michał Karbownik, Piotr Kuna, Michał Panek   +3 more
wiley   +1 more source

Paraneoplastic scleroderma: a patient with a history of breast cancer presenting with sclerodactyly and Raynaud's phenomenon. [PDF]

BMJ Case Rep
Phillips EC, Clark MJ, Schirtzinger M.
europepmc   +1 more source

Elevated CD47 Expression Impairs Elimination of Photoaged Fibroblasts by Macrophages and Serves as a Potential Biomarker for Photoaging

Journal of Cosmetic Dermatology, Volume 24, Issue 4, April 2025.
ABSTRACT Background CD47 could negatively regulate macrophage‐mediated phagocytosis and contribute to senescent cells accumulation in aging. However, it remains unknown whether CD47 is overexpressed in photoaged skin and involved in photoaging pathogenesis.
Xinya Xu, Xinhua Lu, Xinling Chen, Amin Yao, Wei Lai   +4 more
wiley   +1 more source