Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts [PDF]
, 2019 Despite recent progress in its treatment, Multiple Myeloma (MM) remains incurable and its associated bone disease persists even after complete remission.
Atkinson, Emily G. +7 more
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Osteocyte isolation and culture methods. [PDF]
, 2016 The aim of this paper is to present several popular methods for in vitro culture of osteocytes and osteocyte cell lines. Osteocytes are located extremely suitably within the calcified bone matrix to sense mechanical signals, and are equipped with a ...
Bakker, A.D. +5 more
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The Effect Of Light Compressive And Tensile Orthodontics Forces On Sclerostin And Periostin Expressions In Human Periodontal Ligament Cells: An Invitro Study [PDF]
, 2022 Nastaran Sharifi +4 more
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Identification of receptor-type protein tyrosine phosphatase μ as a new marker for osteocytes [PDF]
, 2015 Osteocytes are the predominant cells in bone, where they form a cellular network and display important functions in bone homeostasis, phosphate metabolism and mechanical transduction.
Bezemer, M. (Martineke) +9 more
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Regulation of sclerostin in glucocorticoid-induced osteoporosis (GIO) in mice and humans [PDF]
, 2019 Sylvia Thiele +9 more
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Bone & Joint ResearchAims: The physiological function of sclerostin remains unknown. Sclerostin is synthesized by osteocytes and operates by inhibiting the Wnt/β-catenin pathway. Similarly, it is well established that low levels of sclerostin lead to enhanced bone formation
María Encarnacion Rodríguez-Ortiz +12 more
doaj +1 more source
The role of sclerostin in knee osteoarthritis and its relation to disease progression
The Egyptian Journal of Internal Medicine, 2019 Background Osteoarthritis (OA) is a common joint disease especially in aging population and is characterized by progressive degeneration of articular cartilage, osteophyte formation, and subsequent joint space narrowing.
Amina B Eldin +2 more
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RAGE Signaling in Skeletal Biology [PDF]
, 2019 PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Davis, Hannah M. +2 more
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Sclerostin and occlusion: A brief review
Journal of Indian Society of Periodontology, 2015 In its pursuit of understanding the wonders of human body, mankind has stumbled upon yet another discovery which not only is a key to chest of unanswered queries but also opens a plethora of new possibilities. Till recently the osteocytes were considered latent cells merely entrapped in the matrix of bone. With the discovery of beta-catenin pathway and
Pankaj Bansal +3 more
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Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease [PDF]
, 2016 Homare Eda +11 more
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