Results 161 to 170 of about 25,148 (309)

Sclerostin levels in uremic patients: a link between bone and vascular disease [PDF]

, 2016
Annamaria Bruzzese, Antonio Lacquaniti, Valeria Cernaro, Carlo Alberto Ricciardi, Saverio Loddo, Adolfo Romeo, Gaetano Montalto, Giuseppe Costantino, Francesco La Torre, Giuseppina Pettinato, Ignazio Salamone, Carmela Aloisi, Domenico Santoro, Michele Buemi   +13 more
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Hyperthyroidism and Hypothyroidism in Male Mice and Their Effects on Bone Mass, Bone Turnover, and the Wnt Inhibitors Sclerostin and Dickkopf-1 [PDF]

, 2015
Elena Tsourdi, Eddy Rijntjes, Josef Köhrle, Lorenz C. Hofbauer, Martina Rauner   +4 more
openalex   +1 more source

Sclerostin as a new target of diabetes-induced osteoporosis

Frontiers in Endocrinology
Sclerostin, a protein synthesized by bone cells, is a product of the SOST gene. Sclerostin is a potent soluble inhibitor of the WNT signaling pathway, and is known to inhibit bone formation by inhibiting osteocyte differentiation and function. Currently,
Yanhua Li, Yaheng Luo, Debin Huang, Lele Peng   +3 more
doaj   +1 more source

Tissue-Level Mechanisms Responsible for the Increase in Bone Formation and Bone Volume by Sclerostin Antibody [PDF]

, 2013
Michael S. Ominsky, Qing‐Tian Niu, Chaoyang Li, Xiaodong Li, Hua Zhu Ke   +4 more
openalex   +1 more source

Circulating bioactive sclerostin levels in an Austrian population-based cohort [PDF]

, 2021
Katharina Kerschan‐Schindl, Ursula Föger‐Samwald, Andreas Gleiß, Stefan Kudlacek, Jacqueline Wallwitz, Peter Pietschmann   +5 more
openalex   +1 more source

Sclerostin Small Molecule Inhibitors Promote Osteogenesis by Activating Canonical Wnt and BMP Pathways [PDF]

, 2021
Sreedhara Sangadala, Chi Heon Kim, Lorenzo M. Fernandes, Pooja Makkar, Scott D. Boden, George R. Beck, Hicham Drissi, Steven M. Presciutti   +7 more
openalex   +1 more source

Progress of studies on sclerostin’s role in vascular calcification of chronic kidney disease

Linchuang shenzangbing zazhi, 2019
As an essential messenger between bones and vessel axis,sclerostin plays a key role in development and progression of vascular calcification;however,its mechanism is complicated.Current studies have demonstrated,sclerostin is an osteocyte-specific ...
PENG Qiong-yao, LIU Ling
doaj  

Osteocytes Mechanosensing in NASA Rotating Wall Bioreactor [PDF]

, 2010
Osteocyte cells are the most abundant (90%) yet least understood bone cell type in the human body. Osteocytes are theorized to be the mechanosensors and transducers of mechanical load for bones, yet the biological mechanism of this action remains elusive.
Barry, Kevin, Bouxsein, Mary, Pajevic, Paola Divieti, Sibonga, Jean, Spatz, Jordan, Wu, Honglu   +5 more
core   +1 more source

Serum sclerostin as a biomarker of disease activity in ankylosing spondylitis in correlation with radiographic imaging

Egyptian Rheumatology and Rehabilitation
Background The wingless signaling pathway of bone development is inhibited by sclerostin, which may contribute to the etiology of ankylosing spondylitis.
Nouran Medhat Abd El Samad Sakrana, Nevine Mohamed ElSayed Badr, Manar Ahmed Azab Hassan, Marwa Ahmed Kamel Hassan   +3 more
doaj   +1 more source

Sclerostin Alters Tumor Cell Characteristics of Oral Squamous Cell Carcinoma and May Be a Key Player in Local Bone Invasion

Cells
Localized jawbone invasion is a milestone in the progression of oral squamous cell carcinoma (OSCC). The factors that promote this process are not well understood. Sclerostin is known to be involved in bone metabolism and there are preliminary reports of
Uwe Schirmer, Sina Allegra Schneider, Tatjana Khromov, Felix Bremmer, Boris Schminke, Henning Schliephake, Klaus Liefeith, Phillipp Brockmeyer   +7 more
doaj   +1 more source