Results 191 to 200 of about 1,353,799 (209)

The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts delay-dependent and scopolamine-induced recognition memory deficits in rats

Neurobiology of Learning and Memory, 2017
Experimental evidence indicates that the neurosteroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) are involved in cognition. BNN27 is a novel 17C spiroepoxy-DHEA derivative, which devoid of steroidogenic activity. The neuroprotective effects of BNN27 have been recently reported.
Nikolaos, Pitsikas, Achille, Gravanis
openaire   +2 more sources

Dihuang Yinzi improves scopolamine-induced learning and memory impairment by regulating plasma exosome-derived BDNF

Journal of Ethnopharmacology
Dihuang Drink (DHD), formulated by Liu Hejian during the Yuan Dynasty, is listed as one of the first ancient classical prescriptions by the National Medical Products Administration of China. It is commonly used for the prevention and treatment of Alzheimer's disease (AD).
Wenna Su, Yuzhong Du, Wenting Wang, Qinqing Li, Junlong Zhang, Wenbin He   +5 more
openaire   +2 more sources

Safflower (Carthamus tinctorius L.) seed attenuates memory impairment induced by scopolamine in mice via regulation of cholinergic dysfunction and oxidative stress.

Food & Function, 2019
Cholinergic dysfunction and oxidative stress are the most common causes of Alzheimer's disease (AD). Safflower seed contains various anti-oxidant and cholinergic improvement compounds, such as serotonin and its derivatives.
J. Kim, M. He, Min Jo Kim, Chang Yeol Yang, Y. Shin, T. Yokozawa, C. Park, E. Cho   +7 more
semanticscholar   +1 more source

Design and synthesis of 2-phenyl-1H-benzo[d]imidazole derivatives as 17β-HSD10 inhibitors for the treatment of Alzheimer's disease.

RSC Medicinal Chemistry
It has been reported that 17β-HSD10 plays a key role in Alzheimer's disease. Here, a total of 44 2-phenyl-1H-benzo[d]imidazole derivatives were designed and synthesized as novel 17β-HSD10 inhibitors based on rational design and SAR studies.
Xiaohan Liu, Bin Zhou, Yan Chen, Jinyuan lin, Chenwen Shao, Liuzeng Chen, Banfeng Ruan, Xingxing Zhang, Yong Qian   +8 more
semanticscholar   +1 more source

Semi‐Synthesis and Biological Evaluation of Phyllanthin Derivatives as Potential Neuroprotective Agents

Archiv der Pharmazie
Oxidative stress is responsible for the functional loss and sensory impairment of neurons, which leads to progressive loss of brain and spinal cord cells and contributes significantly to several neurological disorders, thus eventually resulting in brain ...
Bylapudi Lalitha Kumari, Rahul Kumar, Kakade Aditi Sakharam, Rutuja Damare, Shashi Bala Singh, Gautam Kumar   +5 more
semanticscholar   +1 more source

4-Chlorobenzylamine Containing Maleic Acid Derivatives: Synthesis, In Silico Studies, and Anti-Alzheimer's Activity.

ACS Chemical Neuroscience
One way to protect neurons is to protect them from oxidative damage by reducing lipid peroxidation (LPO). Therapeutic medicines that target the inflammatory response have antioxidant activities and can also block inflammatory cascade pathways and ...
Muhammad Junaid Tariq, Madiha Kanwal, Athar Ata, Humaira Nadeem, Mahwish Siddiqui   +4 more
semanticscholar   +1 more source

Combined treatment with pantothenic acid derivatives and memantine alleviates scopolamine-induced amnesia in rats: The involvement of the thiol redox state and coenzyme A

Neurochemical Journal, 2016
M. Stepanichev, D. Markov, S. Freiman, O. Frolova, S. Omelyanchik, T. A. Borodina, M. Novikova, N. Kanunnikova, M. Onufriev, A. Moiseenok, N. Gulyaeva   +10 more
semanticscholar   +2 more sources

Epidural scopolamine derivative injection in patients with chronic pain

Pain, 1990
openaire   +1 more source

Neuroprotective effects of bioactive peptides derived from fermented rice beverage in scopolamine-induced amnesic mice

Proceedings of the Virtual 2020 AOCS Annual Meeting & Expo, 2020
Shigeru Katayama, Soichiro Nakamura
openaire   +1 more source

[The chemistry of tropane derivatives. 3. Synthesis of nor-(--) scopolamine and some norscopine and scopine esters].

Justus Liebigs Annalen der Chemie, 1970
G, Werner, R, Schickfluss
openaire   +2 more sources