Results 171 to 180 of about 6,509 (213)
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Antispasmodics. VIII. Scopolamine Derivatives
Journal of the American Chemical Society, 1956Robert Bruce Moffett +1 more
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Effects of New Galantamine Derivatives in a Scopolamine Model of Dementia in Mice
Journal of Alzheimer's Disease, 2021Alzheimer’s disease (AD), a progressive neurodegenerative disorder characterized by memory loss and cognitive functions decline, is a leading cause for dementia and currently ranked as the sixth foremost cause of death. As of present, treatment of AD is symptomatic without convincing therapeutic benefits and new, effective, therapeutic agents are ...
Maria, Lazarova +10 more
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Pharmacology Biochemistry and Behavior, 2008
The water-soluble derivative of propolis (WSDP) was prepared from fresh Chinese propolis. Its major constituents were identified by high performance liquid chromatography (HPLC) analysis. It has been reported that propolis possessed a broad spectrum of biological activities but including few studies on learning and memory by now.
Juan, Chen +5 more
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The water-soluble derivative of propolis (WSDP) was prepared from fresh Chinese propolis. Its major constituents were identified by high performance liquid chromatography (HPLC) analysis. It has been reported that propolis possessed a broad spectrum of biological activities but including few studies on learning and memory by now.
Juan, Chen +5 more
openaire +2 more sources
Journal of Pharmaceutical Sciences, 1970
The purpose of this study was to develop a procedure for the quantitative analysis of the salts of the solanaceous alkaloids in the presence of their hydrolysis products. The salts taken were atropine sulfate, homatropine hydrobromide, homatropine methyl-bromide, scopolamine hydrobromide, and scopolamine methyl-bromide. The ferric hydroxamate procedure
J A, Feldman, B J, Robb
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The purpose of this study was to develop a procedure for the quantitative analysis of the salts of the solanaceous alkaloids in the presence of their hydrolysis products. The salts taken were atropine sulfate, homatropine hydrobromide, homatropine methyl-bromide, scopolamine hydrobromide, and scopolamine methyl-bromide. The ferric hydroxamate procedure
J A, Feldman, B J, Robb
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Molecular Neurobiology, 2014
Vascular endothelial dysfunction plays a key role in the pathogenesis of Alzheimer's disease (AD). Patients with AD have displayed decreased circulating endothelial progenitor cells (EPCs) which repair and maintain the endothelial function. Transplantation of EPCs has emerged as a promising approach for the management of cerebrovascular diseases ...
Safar, Marwa M. +3 more
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Vascular endothelial dysfunction plays a key role in the pathogenesis of Alzheimer's disease (AD). Patients with AD have displayed decreased circulating endothelial progenitor cells (EPCs) which repair and maintain the endothelial function. Transplantation of EPCs has emerged as a promising approach for the management of cerebrovascular diseases ...
Safar, Marwa M. +3 more
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Journal of Agricultural and Food Chemistry, 2022
The incidence of neurodegenerative diseases related to cognitive decline and memory loss is on the rise as the global elderly population increases. In this study, we evaluated the effect of the sea cucumber-derived peptide Phe-Tyr-Asp-Trp-Pro-Lys (FYDWPK) on scopolamine-induced neurotoxicity in an animal model.
Yue Zhao +4 more
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The incidence of neurodegenerative diseases related to cognitive decline and memory loss is on the rise as the global elderly population increases. In this study, we evaluated the effect of the sea cucumber-derived peptide Phe-Tyr-Asp-Trp-Pro-Lys (FYDWPK) on scopolamine-induced neurotoxicity in an animal model.
Yue Zhao +4 more
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Planta Medica, 1986
We have established clonal cell cultures derived from protoplasts of haploid and diploid Hyoscyamus muticus L. var. Gatersleben (Solanaceae) plants. The scopolamine content of plants and the clones was determined by sensitive enzyme- and radioimmunoassay. Variation in scopolamine content was significant among whole plants.
Oksman-Caldentey, Kirsi-Marja +1 more
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We have established clonal cell cultures derived from protoplasts of haploid and diploid Hyoscyamus muticus L. var. Gatersleben (Solanaceae) plants. The scopolamine content of plants and the clones was determined by sensitive enzyme- and radioimmunoassay. Variation in scopolamine content was significant among whole plants.
Oksman-Caldentey, Kirsi-Marja +1 more
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Scopolamine Derivatives as Potential Pharmaceuticals with Calixarene-CyclodextrineNanosponges as Drug Carriers [PDF]
, 2017 Tropane alkaloids are molecules with a strong biological activity, which are mainly produced by the members offamily Solanaceae, but also found inother plant families (Convolvulaceae, Brasicaceae, Erythroxylaceae andEuphorbiaceae).1 More than 20 active pharmaceutical substances containingthetropane moiety have been industrially produced and applied as ...
G. Rizzo +4 more
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European Journal of Medicinal Chemistry, 2020
Alzheimer's disease is a common neurodegenerative disease characterized by progressive degeneration and neuronal cell death, resulting in neural network dysfunction. As the underlying mechanisms, oxidative damage and neuroinflammation have been reported to contribute to the onset and deterioration of Alzheimer's disease.
Hyeon Jeong Kim +9 more
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Alzheimer's disease is a common neurodegenerative disease characterized by progressive degeneration and neuronal cell death, resulting in neural network dysfunction. As the underlying mechanisms, oxidative damage and neuroinflammation have been reported to contribute to the onset and deterioration of Alzheimer's disease.
Hyeon Jeong Kim +9 more
openaire +2 more sources
Journal of Agricultural and Food Chemistry, 2022
The purpose of this study was to investigate the neuroprotective effect of Arg-containing peptides from walnut storage protein sequences in scopolamine-induced zebrafish and further to validate the potential neuroprotection of Arg-containing peptide enriched walnut hydrolysates prepared by in silico hydrolysis and controlled enzymatic release.
Shuguang Wang +6 more
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The purpose of this study was to investigate the neuroprotective effect of Arg-containing peptides from walnut storage protein sequences in scopolamine-induced zebrafish and further to validate the potential neuroprotection of Arg-containing peptide enriched walnut hydrolysates prepared by in silico hydrolysis and controlled enzymatic release.
Shuguang Wang +6 more
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