Results 161 to 170 of about 6,509 (213)

The role of Aß-peptide on spatial memory, EEG, auditory evoked potential and nicotinic cholinergic receptors in A/P transgenic mice (Amyloidi ß-peptidin osuus Alzheimerin taudin mallina käytettävien A/P siirtogeenisten hiirten paikkamuistihäiriössä, EEG- ja kuuloherätevastelöydöksissä sekä kolinergisissa nikotiinireseptoreissa tavatuissa muutoksissa) [PDF]

Wang, Jun
core  

Toxic and Hallucinogenic Plants of Southern Chile of Forensic Interest: A Review. [PDF]

Plants (Basel)
Díaz R, Yáñez-Sánchez M, de la Fuente F, Ortega A, Figueroa-Carvajal A, Gangitano D, Scholz-Wagenknecht O.   +6 more
europepmc   +1 more source

Annotated Bibliography: Anticipation [PDF]

, 2010
Nadin, Mihai
core  

Evaluation of the Ameliorative Potential of 3,5-bis(2-hydroxyethyl)-1,3,5-thiadiazinane-2-thione against Scopolamine-Induced Alzheimer's Disease. [PDF]

Int J Mol Sci
Shagufta, Ali G, Khan A, Rasheed A, Deeba F, Ullah R, Shahid M, Ali H, Khan R, Shamezai N, Sharif N.   +10 more
europepmc   +1 more source

Water extract of <i>Humulus japonicus</i> improves age‑related cognitive decline by inhibiting acetylcholinesterase activity and the acetylcholine signaling pathway. [PDF]

Mol Med Rep
Kim JE, Min KS, Go J, Park HY, Choi YK, Lee IB, Shin J, Cho HJ, Kim HS, Hwang DY, Oh WK, Kim KS, Lee CH.   +12 more
europepmc   +1 more source

Neuroprotective Potential of Phytocompounds in the Treatment of Dementia: The State of Knowledge from the Scopolamine-Induced Animal Model of Alzheimer's Disease. [PDF]

Curr Issues Mol Biol
Szala-Rycaj J, Zagaja M, Szewczyk A, Polak J, Andres-Mach M.   +4 more
europepmc   +1 more source

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Ameliorative effects of amide derivatives of 1,3,4-thiadiazoles on scopolamine induced cognitive dysfunction

European Journal of Medicinal Chemistry, 2016
The present study reports the effect of amide derivatives of 1,3,4-thiadizoles on scopolamine induced deficit cholinergic neurotransmission and oxidative stress serving as promising leads for the therapeutics of cognitive dysfunction. Fourteen compounds (2c-8d) have been synthesised and evaluated against behavioural alterations using step down passive ...
Akanksha Kulshreshtha, Poonam Piplani
exaly   +3 more sources

Validated capillary electrophoresis method for the determination of atropine and scopolamine derivatives in pharmaceutical formulations

Journal of Pharmaceutical and Biomedical Analysis, 1998
The simultaneous determination of atropine and scopolamine derivatives, which have similar structures, was investigated by using capillary zone electrophoresis. The effects of buffer pH, buffer concentration and hydroxypropyl-beta-cyclodextrin concentration on migration time and resolution of the investigated compounds were systematically studied.
Philippe Christen, Jean-Luc Veuthey
exaly   +4 more sources

Neuroprotective effects of novel pyrrolidine-2-one derivatives on scopolamine-induced cognitive impairment in mice: Behavioral and biochemical analysis

Pharmacology Biochemistry and Behavior, 2023
Alzheimer's disease (AD) is a long-term neurodegenerative condition that impairs cognitive abilities. In brain acetylcholine deficit and oxidative stress may be considered the key pathogenic causes for AD, even though the basic etiology is still unknown.
Swati Pant, Sumitra Nain
exaly   +3 more sources

Design and development of 1,3,4-oxadiazole derivatives as potential inhibitors of acetylcholinesterase to ameliorate scopolamine-induced cognitive dysfunctions

Bioorganic Chemistry, 2019
The novel hybrids bearing 4-aminopyridine (4-AP) tethered with substituted 1,3,4-oxadiazole nucleus were designed, synthesized, and evaluated for their potential AChE inhibitory property along with significant antioxidant potential. The inhibitory potential (IC50) of synthesized analogs was evaluated against human cholinesterases (hAChE and hBChE ...
Piyoosh Sharma, Prabhash Nath Tripathi, Sukesh Kumar Gupta   +2 more
exaly   +3 more sources