Results 161 to 170 of about 627,170 (198)
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Pharmacology Biochemistry and Behavior, 2023
Alzheimer's disease (AD) is a long-term neurodegenerative condition that impairs cognitive abilities. In brain acetylcholine deficit and oxidative stress may be considered the key pathogenic causes for AD, even though the basic etiology is still unknown.
Dr. Sumitra Nain, Monika Chauhan
exaly +3 more sources
Alzheimer's disease (AD) is a long-term neurodegenerative condition that impairs cognitive abilities. In brain acetylcholine deficit and oxidative stress may be considered the key pathogenic causes for AD, even though the basic etiology is still unknown.
Dr. Sumitra Nain, Monika Chauhan
exaly +3 more sources
Pharmacology Biochemistry and Behavior, 2008
The water-soluble derivative of propolis (WSDP) was prepared from fresh Chinese propolis. Its major constituents were identified by high performance liquid chromatography (HPLC) analysis. It has been reported that propolis possessed a broad spectrum of biological activities but including few studies on learning and memory by now.
Juan, Chen +5 more
openaire +2 more sources
The water-soluble derivative of propolis (WSDP) was prepared from fresh Chinese propolis. Its major constituents were identified by high performance liquid chromatography (HPLC) analysis. It has been reported that propolis possessed a broad spectrum of biological activities but including few studies on learning and memory by now.
Juan, Chen +5 more
openaire +2 more sources
European Journal of Medicinal Chemistry, 2020
Alzheimer's disease is a common neurodegenerative disease characterized by progressive degeneration and neuronal cell death, resulting in neural network dysfunction. As the underlying mechanisms, oxidative damage and neuroinflammation have been reported to contribute to the onset and deterioration of Alzheimer's disease.
Hyeon Jeong Kim +9 more
openaire +2 more sources
Alzheimer's disease is a common neurodegenerative disease characterized by progressive degeneration and neuronal cell death, resulting in neural network dysfunction. As the underlying mechanisms, oxidative damage and neuroinflammation have been reported to contribute to the onset and deterioration of Alzheimer's disease.
Hyeon Jeong Kim +9 more
openaire +2 more sources
Bioorganic Chemistry, 2019
The novel hybrids bearing 4-aminopyridine (4-AP) tethered with substituted 1,3,4-oxadiazole nucleus were designed, synthesized, and evaluated for their potential AChE inhibitory property along with significant antioxidant potential. The inhibitory potential (IC50) of synthesized analogs was evaluated against human cholinesterases (hAChE and hBChE ...
Prabhash Nath Tripathi +2 more
exaly +3 more sources
The novel hybrids bearing 4-aminopyridine (4-AP) tethered with substituted 1,3,4-oxadiazole nucleus were designed, synthesized, and evaluated for their potential AChE inhibitory property along with significant antioxidant potential. The inhibitory potential (IC50) of synthesized analogs was evaluated against human cholinesterases (hAChE and hBChE ...
Prabhash Nath Tripathi +2 more
exaly +3 more sources
Planta Medica, 1986
We have established clonal cell cultures derived from protoplasts of haploid and diploid Hyoscyamus muticus L. var. Gatersleben (Solanaceae) plants. The scopolamine content of plants and the clones was determined by sensitive enzyme- and radioimmunoassay. Variation in scopolamine content was significant among whole plants.
Oksman-Caldentey, Kirsi-Marja +1 more
openaire +1 more source
We have established clonal cell cultures derived from protoplasts of haploid and diploid Hyoscyamus muticus L. var. Gatersleben (Solanaceae) plants. The scopolamine content of plants and the clones was determined by sensitive enzyme- and radioimmunoassay. Variation in scopolamine content was significant among whole plants.
Oksman-Caldentey, Kirsi-Marja +1 more
openaire +1 more source
Neurotoxicity Research
Aminopyrimidine compounds have been gaining traction in the field of drug discovery in recent years due to their emergence as multi-targeted molecules. This makes them perfect candidates as agents for cognitive improvement, as cognitive decline is a multifaceted condition.
Behnaz, Landi +6 more
openaire +2 more sources
Aminopyrimidine compounds have been gaining traction in the field of drug discovery in recent years due to their emergence as multi-targeted molecules. This makes them perfect candidates as agents for cognitive improvement, as cognitive decline is a multifaceted condition.
Behnaz, Landi +6 more
openaire +2 more sources
Neurobiology of Learning and Memory, 2017
Experimental evidence indicates that the neurosteroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) are involved in cognition. BNN27 is a novel 17C spiroepoxy-DHEA derivative, which devoid of steroidogenic activity. The neuroprotective effects of BNN27 have been recently reported.
Nikolaos, Pitsikas, Achille, Gravanis
openaire +2 more sources
Experimental evidence indicates that the neurosteroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) are involved in cognition. BNN27 is a novel 17C spiroepoxy-DHEA derivative, which devoid of steroidogenic activity. The neuroprotective effects of BNN27 have been recently reported.
Nikolaos, Pitsikas, Achille, Gravanis
openaire +2 more sources
Mini-Reviews in Medicinal Chemistry, 2018
Background:Currently, there is no conclusive cure for Alzheimer’s disease (AD) and existing treatments mainly offer symptomatic relief. Dysfunction of the cholinergic system plays an important role in the pathogenesis of AD. Tacrine (1, 2, 3, 4-tetrahydroacridin-9-amine, III) was the first approved agent for the palliative therapy of AD but its use is ...
Abbas, Ahmadi +3 more
openaire +2 more sources
Background:Currently, there is no conclusive cure for Alzheimer’s disease (AD) and existing treatments mainly offer symptomatic relief. Dysfunction of the cholinergic system plays an important role in the pathogenesis of AD. Tacrine (1, 2, 3, 4-tetrahydroacridin-9-amine, III) was the first approved agent for the palliative therapy of AD but its use is ...
Abbas, Ahmadi +3 more
openaire +2 more sources
Molecular Neurobiology, 2014
Vascular endothelial dysfunction plays a key role in the pathogenesis of Alzheimer's disease (AD). Patients with AD have displayed decreased circulating endothelial progenitor cells (EPCs) which repair and maintain the endothelial function. Transplantation of EPCs has emerged as a promising approach for the management of cerebrovascular diseases ...
Safar, Marwa M. +3 more
openaire +2 more sources
Vascular endothelial dysfunction plays a key role in the pathogenesis of Alzheimer's disease (AD). Patients with AD have displayed decreased circulating endothelial progenitor cells (EPCs) which repair and maintain the endothelial function. Transplantation of EPCs has emerged as a promising approach for the management of cerebrovascular diseases ...
Safar, Marwa M. +3 more
openaire +2 more sources
Journal of Ethnopharmacology
Dihuang Drink (DHD), formulated by Liu Hejian during the Yuan Dynasty, is listed as one of the first ancient classical prescriptions by the National Medical Products Administration of China. It is commonly used for the prevention and treatment of Alzheimer's disease (AD).
Wenna Su +5 more
openaire +2 more sources
Dihuang Drink (DHD), formulated by Liu Hejian during the Yuan Dynasty, is listed as one of the first ancient classical prescriptions by the National Medical Products Administration of China. It is commonly used for the prevention and treatment of Alzheimer's disease (AD).
Wenna Su +5 more
openaire +2 more sources