Results 181 to 190 of about 6,509 (213)
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The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts delay-dependent and scopolamine-induced recognition memory deficits in rats

Neurobiology of Learning and Memory, 2017
Experimental evidence indicates that the neurosteroids dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) are involved in cognition. BNN27 is a novel 17C spiroepoxy-DHEA derivative, which devoid of steroidogenic activity. The neuroprotective effects of BNN27 have been recently reported.
Nikolaos, Pitsikas, Achille, Gravanis
openaire   +2 more sources

Dihuang Yinzi improves scopolamine-induced learning and memory impairment by regulating plasma exosome-derived BDNF

Journal of Ethnopharmacology
Dihuang Drink (DHD), formulated by Liu Hejian during the Yuan Dynasty, is listed as one of the first ancient classical prescriptions by the National Medical Products Administration of China. It is commonly used for the prevention and treatment of Alzheimer's disease (AD).
Wenna Su   +5 more
openaire   +2 more sources

Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5)

ACS Chemical Neuroscience, 2018
On the basis of the drug-repositioning and redeveloping strategy, first-generation dual-target inhibitors of acetylcholinesterase (AChE) and phosphodiesterase 5 (PDE5) have been recently reported as a potentially novel therapeutic method for the treatment of Alzheimer's disease (AD), and the lead compound 2 has proven this method was feasible in AD ...
Wei Ni   +10 more
openaire   +2 more sources

Evaluation of the Memory Enhancement Effects of Aminopyrimidine Derivatives Using the Scopolamine Model of Dementia in Mice

Neurotoxicity Research
Aminopyrimidine compounds have been gaining traction in the field of drug discovery in recent years due to their emergence as multi-targeted molecules. This makes them perfect candidates as agents for cognitive improvement, as cognitive decline is a multifaceted condition.
Behnaz, Landi   +6 more
openaire   +2 more sources

Synthesis and evaluation of enzyme inhibitory potential of some derivatives of scopolamine

Turkish Journal of Chemistry, 2012
TANIA KHAN   +2 more
openaire   +1 more source

Ameliorative effects of 1,3,4-thiadiazole derivatives on scopolamine induced cognitive deficits in mice

Parkinsonism & Related Disorders, 2016
Akanksha Kulshreshtha, Poonam Piplani
openaire   +1 more source

Scopolamine, a Toxin-Induced Experimental Model, Used for Research in Alzheimer’s Disease

CNS and Neurological Disorders - Drug Targets, 2020
Win Ning Chen, Keng Yoon Yeong
exaly  

Neuroprotective effects of bioactive peptides derived from fermented rice beverage in scopolamine-induced amnesic mice

Proceedings of the Virtual 2020 AOCS Annual Meeting & Expo, 2020
Shigeru Katayama, Soichiro Nakamura
openaire   +1 more source

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