Results 61 to 70 of about 2,536,246 (313)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Testing for zero-modification in count regression models [PDF]

, 2006
Count data often exhibit overdispersion and/or require an adjustment for zero outcomes with respect to a Poisson model. Zero-modified Poisson (ZMP) and zero-modified generalized Poisson (ZMGP) regression models are useful classes of models for such ...
Min, Aleksey, Czado, Claudia
core   +1 more source

Testing Homogeneity of Proportion Ratios for Stratified Bilateral Correlated Data

Mathematical and Computational Applications
Intraclass correlation in bilateral data has been investigated in recent decades with various statistical methods. In practice, stratifying bilateral data by some control variables will provide more sophisticated statistical results to satisfy different ...
Wanqing Tian, Changxing Ma
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Predicting streptococcal pharyngitis in adults in primary care: a systematic review of the diagnostic accuracy of symptoms and signs and validation of the Centor score [PDF]

, 2011
Background: Stratifying patients with a sore throat into the probability of having an underlying bacterial or viral cause may be helpful in targeting antibiotic treatment.
O'Brien Kirsty K, Borislav D Dimitrov, Gavin A Falk, Chan, Wai-Sun, Conor Teljeur (4864684), Wai-Sun Chan (32336), Aalbers Jolien, Fahey Tom, Jolien Aalbers, Chan Wai-Sun, Jolien Aalbers (7944122), Teljeur Conor, Gavin A. Falk (7944125), Aalbers, Jolien, Kirsty K. O'Brien (7943054), Tom Fahey (7896266), Teljeur, Conor, Conor Teljeur, Dimitrov, Borislav D., Tom Fahey, Borislav D. Dimitrov (7942988), Dimitrov Borislav D, Wai-Sun Chan, Fahey, Tom, O'Brien, Kirsty K., Falk Gavin A, Kirsty K O'Brien, Falk, Gavin A.   +27 more
core   +1 more source

Computational Approach Test using Likelihood Based Tests for the Equality of Inverse Gaussian Means

Revstat Statistical Journal
In this study, we propose three different test procedures by plugging the Wald (W), score (S) and likelihood ratio (LR) statistics into the computational approach test (CAT) to test the equality of inverse Gaussian means when the scale parameters are ...
Gamze Güven , Hatice Şamkar, Fikri Gökpinar   +2 more
doaj   +1 more source

A Comparative Study of the Results of the Anatomic Medial Portal and All-inside Arthroscopic Acl Reconstruction [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Many techniques of graft placement in Arthroscopic Anterior Cruciate Ligament (ACL) reconstruction is available nowa-days, like trans-tibial, anatomical accessory medial portal and anatomical all-inside technique.
KUMAR SHANTANU, SUDHIR SHYAM KUSHWAHA, DEEPAK KUMAR, VINEET KUMAR, SHAILENDRA SINGH, VINEET SHARMA   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Haplotype-based score test for linkage in nuclear families

BMC Bioinformatics, 2007
Background To look for genetic linkage between angiotensin-I converting enzyme(ACE) gene and hypertension in a Korean adolescent cohort, we developed a powerful test using the covariances between marginal differences and their variances in a transmission/
Kang Dae Ryong, Nam Chung Mo, Kim Jinheum   +2 more
doaj   +1 more source