Results 81 to 90 of about 1,501,990 (289)

Evaluating probability forecasts in terms of refinement and strictly proper scoring rules [PDF]

This note gives an easily verified necessary and sufficient condition for one probability forecaster to empirically outperform another one in terms of all strictly proper scoring rules.
Krämer, Walter
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Aligned Textual Scoring Rules

CoRR
Scoring rules elicit probabilistic predictions from a strategic agent by scoring the prediction against a ground truth state. A scoring rule is proper if, from the agent's perspective, reporting the true belief maximizes the expected score. With the development of language models, Wu and Hartline (2024) proposes a reduction from textual information ...
Yuxuan Lu 0001, Yifan Wu, Jason Hartline, Michael J. Curry   +3 more
openaire   +3 more sources

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Distance Rationalizability of Scoring Rules [PDF]

, 2015
Collective decision making problems can be seen as finding an outcome that is "closest" to a concept of "consensus". [1] introduced "Closeness to Unanimity Procedure" as a first example to this approach and showed that the Borda rule is the closest to unanimity under swap distance (a.k.a the [2] distance). [3] shows that the Dodgson rule is the closest
openaire   +5 more sources

Committee Scoring Rules

ACM Transactions on Economics and Computation, 2019
Committee scoring voting rules are multiwinner analogues of positional scoring rules, which constitute an important subclass of single-winner voting rules. We identify several natural subclasses of committee scoring rules, namely, weakly separable, representation-focused, top- k -counting, OWA-based, and ...
Piotr Faliszewski, Piotr Skowron 0001, Arkadii Slinko, Nimrod Talmon   +3 more
openaire   +5 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Variable-population voting rules [PDF]

Let X be a set of social alternatives, and let V be a set of `votes' or `signals'. (We do not assume any structure on X or V). A `variable population voting rule' F takes any number of anonymous votes drawn from V as input, and produces a nonempty subset
Pivato, Marcus
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

On incentive compatible designs of forecasting contracts

Quantitative Methods in Economics, 2010
In the paper the optimal design of forecasting contracts in principalagent setting is investigated. It is assumed that the principal pays the agent (theforecaster) based on an announced forecast and an event that materializes next.Such a contract is ...
Bogumił Kamiński
doaj