Results 81 to 90 of about 11,746 (218)

Gene and Genome Duplication in Spiders

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 344, Issue 7, Page 379-393, November 2025.
In chelicerates whole genome duplications (WGDs) were identified in distinct groups. While there is evidence that Xiphosurans/horseshoe crabs had three rounds of WGD and arachnopulmonates (e.g. spiders and scorpions) had one WGD, in many other arachnid groups no WGD was identified.
Chetan Munegowda, Matthias Pechmann, Nikola‐Michael Prpic‐Schäper, Natascha Turetzek   +3 more
wiley   +1 more source

Short Peptides from Asian Scorpions: Bioactive Molecules with Promising Therapeutic Potential

Toxins
Scorpion venom peptides, particularly those derived from Asian species, have garnered significant attention, offering therapeutic potential in pain management, cancer, anticoagulation, and infectious diseases.
Kaiyun Xin, Ruize Sun, Wanyang Xiao, Weijie Lu, Chenhui Sun, Jietao Lou, Yanyan Xu, Tianbao Chen, Di Wu, Yitian Gao   +9 more
doaj   +1 more source

Functional Properties and Toxin Pharmacology of a Dorsal Root Ganglion Sodium Channel Viewed through its Voltage Sensors [PDF]

, 2013
The voltage-activated sodium (Nav) channel Nav1.9 is expressed in dorsal root ganglion (DRG) neurons where it is believed to play an important role in nociception.
Bean, Bruce Palmer, Bosmans, Frank, Martin-Eauclaire, Marie-France, Puopolo, Michelino, Swartz, Kenton J.   +4 more
core   +1 more source

Structural similarities reveal an expansive conotoxin family with a two‐finger toxin fold

Protein Science, Volume 34, Issue 11, November 2025.
Abstract Venomous animals have evolved a diverse repertoire of toxins with considerable pharmaceutical potential. The rapid evolution of peptide toxins, such as the conotoxins produced by venomous marine cone snails, often complicates efforts to infer their evolutionary relationships based solely on sequence information.
Muhammad Saad Khilji, Celeste M. Hackney, Thomas L. Koch, Arik J. Hone, Aymeric Rogalski, Maren Watkins, Jortan Tun, J. Michael McIntosh, Baldomero Olivera, Helena Safavi‐Hemami, Kaare Teilum, Lars Ellgaard   +11 more
wiley   +1 more source

Partial purification of peptides present in the Tityus macrochirus (Buthidae) scorpion venom and preliminary assessment of their cytotoxicity

Biomédica: revista del Instituto Nacional de Salud, 2017
Introduction: Scorpion venom contains peptides with neurotoxic action primarily active on ion channels in the nervous system of insects and mammals. They are also characterized as cytolytic and anticancer, biological characteristics that have not yet ...
Clara Andrea Rincón-Cortés, Edgar Antonio Reyes-Montaño, Nohora Angélica Vega-Castro   +2 more
doaj   +1 more source

Cardiotoxic and Arrhythmogenic Effects of Hemiscorpius lepturus Scorpion Venom in Rats [PDF]

, 2015
Background: Envenomation by Hemiscorpius lepturus is not painful and the clinical manifestations include bloody urine due to hemoglobinuria or hematuria, dermonecrotic reactions,cardiac arrhythmia and in minority of cases acute renal failure which may ...
Evazy, Reihane, Hoseiny, Seyed Mehdi, Kamyab, Mostafa, Kim, Euikyung, Mashayekhy, Navid Reza, Mirakabadi, Abbas Zare, Pourkhalili, Khalil, Seyedian, Ramin   +7 more
core   +2 more sources

Unveiling the Evolutionary History of European Vipers and Their Venoms From a Multi‐Omic Approach

Molecular Ecology, Volume 34, Issue 21, November 2025.
ABSTRACT Snake genomes attract significant attention from multiple disciplines, including medicine, drug bioprospection, and evolutionary biology. However, genomic research within the Viperidae family has mostly focused on the subfamily Crotalinae, while the true vipers (Viperinae) have largely been overlooked.
Adrián Talavera, Marc Palmada‐Flores, Fernando Martínez‐Freiría, Gabriel Mochales‐Riaño, Bernat Burriel‐Carranza, Maria Estarellas, Daniel Fernández‐Guiberteau, Álvaro Camina, Sylvain Ursenbacher, Judit Vörös, Bálint Halpern, Davinia Pla, Juan José Calvete, Alexander S. Mikheyev, Tomàs Marquès‐Bonet, Salvador Carranza   +15 more
wiley   +1 more source

Scorpion Venom Causes Apoptosis by Increasing Reactive Oxygen Species and Cell Cycle Arrest in MDA-MB-231 and HCT-8 Cancer Cell Lines

Journal of Evidence-Based Integrative Medicine, 2018
Objectives. The objective of this study was to examine the effect of scorpion venoms on cancer cell progression, apoptosis, and cell cycle arrest. Scorpion venoms are known to possess numerous bioactive compounds that act against cancer progression by ...
Abdulrahman Khazim Al-Asmari PhD, Anvarbatcha Riyasdeen PhD, Mozaffarul Islam PhD   +2 more
doaj   +1 more source

Exon Shuffling and Origin of Scorpion Venom Biodiversity

Toxins, 2016
Scorpion venom is a complex combinatorial library of peptides and proteins with multiple biological functions. A combination of transcriptomic and proteomic techniques has revealed its enormous molecular diversity, as identified by the presence of a ...
Xueli Wang, Bin Gao, Shunyi Zhu
doaj   +1 more source

Scorpion Venom and the Inflammatory Response [PDF]

Mediators of Inflammation, 2010
Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. These venoms are associated with high morbility and mortality, especially among children. Victims of envenoming by a scorpion suffer a
openaire   +3 more sources