Results 131 to 140 of about 2,790 (169)

Peptides with therapeutic potential in the venom of the scorpion Buthus martensii Karsch

Peptides, 2019
The scorpion Buthus martensii Karsch (BmK) has generated significant interest due to the presence of biologically active peptides in its venom. In the past decade, dozens of different peptides from BmK have been identified. Most of the peptides are neurotoxins and are responsible for the toxicity of BmK venom.
Zhongjie Li, Wenlan Wu
exaly   +3 more sources

Scorpion and spider venom peptides: Gene cloning and peptide expression

Toxicon, 2011
This communication reviews most of the important findings related to venom components isolated from scorpions and spiders, mainly by means of gene cloning and expression. Rather than revising results obtained by classical biochemical studies that report structure and function of venom components, here the emphasis is placed on cloning and ...
V, Quintero-Hernández, E, Ortiz, M, Rendón-Anaya, E F, Schwartz, B, Becerril, G, Corzo, L D, Possani   +6 more
openaire   +2 more sources

Inhibition of CFTR channels by a peptide toxin of scorpion venom

American Journal of Physiology-Cell Physiology, 2004
Peptide toxins have been valuable probes in efforts to identify amino acid residues that line the permeation pathway of cation-selective channels. However, no peptide toxins have been identified that interact with known anion-selective channels such as the cystic fibrosis transmembrane conductance regulator (CFTR).
Matthew D, Fuller, Zhi-Ren, Zhang, Guiying, Cui, Julia, Kubanek, Nael A, McCarty   +4 more
openaire   +2 more sources

Characterization of peptide components in the venom of the scorpion Liocheles australasiae (Hemiscorpiidae)

Toxicon, 2007
Scorpion venoms are composed of a number of neurotoxic peptides. A variety of toxins have been isolated from the venoms of scorpions of the family Buthidae, however, little interest has been paid to non-Buthidae scorpions. In this study, we examined the toxicity of the venom of Liocheles australasiae (Hemiscorpiidae) to mice and crickets, and ...
Masahiro, Miyashita, Junko, Otsuki, Yosuke, Hanai, Yoshiaki, Nakagawa, Hisashi, Miyagawa   +4 more
openaire   +2 more sources

Evidence for the Existence of Insect Defensin‐Like Peptide in Scorpion Venom

IUBMB Life, 2000
AbstractInsect defensin refers to a group of antibacterial peptides derived from a variety of insect species as well as from scorpion and possessing a three‐dimensional structure highly similar to that of scorpion toxins. A full‐length cDNA encoding an insect defensin‐like peptide was isolated from the venom gland cDNA library of the Chinese ...
S, Zhu, W, Li, D, Jiang, X, Zeng
openaire   +2 more sources

Bioactive peptides from scorpion venoms: therapeutic scaffolds and pharmacological tools

Chinese Journal of Natural Medicines, 2023
Evolution and natural selection have endowed animal venoms, including scorpion venoms, with a wide range of pharmacological properties. Consequently, scorpions, their venoms, and/or their body parts have been used since time immemorial in traditional medicines, especially in Africa and Asia.
Kamau, Peter Muiruri, Jian, Zhong, Bing, Yao, Ren, Lai, Lei, Luo   +4 more
openaire   +2 more sources

Overview of the Knottin scorpion toxin-like peptides in scorpion venoms: Insights on their classification and evolution

Toxicon, 2015
Scorpion venoms include several compounds with different pharmacological activities. Within these compounds, toxins affecting ion channels are among the most studied. They are all peptides that have been classified based on their 3D structure, chain size and function.
Carlos E. Santibáñez-López, Lourival D. Possani   +1 more
openaire   +2 more sources

Anticancer and antimicrobial activities of scorpion venoms and their peptides

Toxin Reviews, 2017
AbstractScorpion venom is a natural biological resource that contains several components, which are not only responsible for death but also have a potential therapeutic activity. Scorpion venom has been used as traditional and folk therapy in various pathophysiological conditions.
openaire   +1 more source

Tityus serrulatus Hypotensins: A new family of peptides from scorpion venom

Biochemical and Biophysical Research Communications, 2008
Using a proteomic approach, a new structural family of peptides was put in evidence in the venom of the yellow scorpion Tityus serrulatus. Tityus serrulatus Hypotensins (TsHpt) are random-coiled linear peptides and have a similar bradykinin-potentiating peptide (BPP) amino acid signature.
Verano-Braga, T., Rocha-Resende, C., Silva, D. M., Ianzer, D., Martin-Eauclaire, M. F., Bougis, P. E., de Lima, M. E., Santos, R. A. S., Pimenta, A. M. C.   +8 more
openaire   +2 more sources

Scorpion Venom Peptides in Ophthalmology: Insights from the Babylonian Talmud

American Journal of Ophthalmology
Historical medical texts can reveal overlooked therapeutic approaches relevant to modern ophthalmology. This perspective revisits a remedy from the Babylonian Talmud prescribing a mixture of scorpion and kohl for an eye condition called buruqti (also transliterated as beroketi), traditionally translated as cataract.
David Maskill, Robert Morgan Blizzard
openaire   +2 more sources