Unraveling neuroprotection with Kv1.3 potassium channel blockade by a scorpion venom peptide [PDF]
Scientific ReportsVoltage-gated potassium channels play a crucial role in cellular repolarization and are potential therapeutic targets in neuroinflammatory disorders and neurodegenerative diseases.
Emidio Beraldo-Neto +6 more
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BmK-YA, an enkephalin-like peptide in scorpion venom. [PDF]
PLoS ONE, 2012 By screening extracts of venom from the Asian scorpion Buthus martensii Karsch (BmK) for their abilities to activate opioid receptors, we have identified BmK-YA, an amidated peptide containing an enkephalin-like sequence. BmK-YA is encoded by a precursor
Yan Zhang +5 more
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A scorpion venom peptide derivative BmKn‒22 with potent antibiofilm activity against Pseudomonas aeruginosa. [PDF]
PLoS ONE, 2019 Pseudomonas aeruginosa is a leading cause of nosocomial and serious life-threatening infections and infections caused by this bacterium continue to pose a major medical challenge worldwide. The ability of P.
Kittitat Teerapo +3 more
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Functional evolution of scorpion venom peptides with an inhibitor cystine knot fold [PDF]
Bioscience Reports, 2013 The ICK (inhibitor cystine knot) defines a large superfamily of polypeptides with high structural stability and functional diversity. Here, we describe a new scorpion venom-derived K+ channel toxin (named λ-MeuKTx-1) with an ICK fold through gene ...
Bin Gao +5 more
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Scorpion Venom Neurotoxins: Molecular Diversity, Mechanisms, and Drug Scaffolds [PDF]
ToxinsVenom is a key evolutionary innovation of venomous organisms in the long-term process of survival adaptation. As one of the oldest arthropods, scorpions produce venom rich in bioactive peptides that also constitute a valuable pharmacological resource ...
Yun Huang +4 more
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Scorpion Venom peptide, AGAP inhibits TRPV1 and potentiates the analgesic effect of lidocaine [PDF]
Heliyon, 2021 Sylvanus Kampo, Wen Qingping
exaly +2 more sources
Frontiers in Pharmacology, 2016 Scorpion venom heat-resistant peptide (SVHRP) is a component purified from Buthus martensii Karsch scorpion venom. Our previous studies found SVHRP could enhance neurogenesis and inhibit microglia-mediated neuroinflammation in vivo.
Xiao-Gang Zhang +8 more
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Stinging Salvation: Harnessing Scorpion Venom Peptides for Revolutionary Pain Relief [PDF]
ToxinsPeptides from scorpion venom, mainly in species such as Olivierus martensii (formerly Olivierus martensii Karsch, often designated BMK) (BmK) and Tityus serrulatus from the Buthidae family, show real promise as painkillers that skip opioids altogether ...
Reza Mosaddeghi-Heris +6 more
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Peptidomics and pharmacological profiling of Odontobuthus doriae (Buthidae) scorpion venom at the kappa opioid receptor [PDF]
Scientific ReportsScorpion venoms are rich in bioactive peptides, many of which act on ion channels and neurotransmitter systems, yet their capacity to interact with G protein-coupled receptors (GPCRs) has been largely unexplored.
Adel Abdollahnia +6 more
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Acetylcholinesterase inhibitory potential of scorpion venom in Aedes aegypti (Diptera: Culicidae) [PDF]
Brazilian Journal of Biology, 2022 Scorpion venom contains a variety of neurotoxins which interact with ion channels and affect their activities. The present study was designed to evaluate the potential of scorpion venom as acetylcholinesterase (AChE) inhibitor by using Aedes aegypti as ...
N. Riaz +6 more
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