Unraveling neuroprotection with Kv1.3 potassium channel blockade by a scorpion venom peptide [PDF]
Scientific ReportsVoltage-gated potassium channels play a crucial role in cellular repolarization and are potential therapeutic targets in neuroinflammatory disorders and neurodegenerative diseases.
Emidio Beraldo-Neto +6 more
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A scorpion venom peptide derivative BmKn‒22 with potent antibiofilm activity against Pseudomonas aeruginosa. [PDF]
PLoS ONE, 2019 Pseudomonas aeruginosa is a leading cause of nosocomial and serious life-threatening infections and infections caused by this bacterium continue to pose a major medical challenge worldwide. The ability of P.
Kittitat Teerapo +3 more
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Scorpion Venom Neurotoxins: Molecular Diversity, Mechanisms, and Drug Scaffolds [PDF]
ToxinsVenom is a key evolutionary innovation of venomous organisms in the long-term process of survival adaptation. As one of the oldest arthropods, scorpions produce venom rich in bioactive peptides that also constitute a valuable pharmacological resource ...
Yun Huang +4 more
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Scorpion venom as a source of new antimicrobial agents [PDF]
Frontiers in MicrobiologyThe escalating global threat of antimicrobial resistance necessitates urgent discovery of novel therapeutic agents. Scorpion venom, a complex cocktail of bioactive molecules, has emerged as a promising reservoir of antimicrobial peptides (AMPs) with ...
Yuanyuan Zhang, Rongqian Wu
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Identification and expression analysis of antibacterial peptides from venom of the scorpion Mesobuthus martensii [PDF]
Frontiers in MicrobiologyIntroductionAs one kind of important component of animal innate immune system, many antibacterial peptides (ABPs) have been characterized from scorpion venoms.
Gaomin Liu +6 more
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The chromosome-level genome of [PDF]
Pharmaceutical Science AdvancesMesobuthus martensii , the source species of the traditional Chinese medicine “Quanxie”, has long been utilized for its therapeutic properties. Venom peptides are recognized as the major active molecular basis of these pharmacological activities. Despite
Daixi Liu +10 more
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Characterization of a Ten-Cysteine Peptide from Scorpion That Inhibits Classical Complement Activation via C4/C4b [PDF]
BiomoleculesScorpion toxin peptides are useful bioactive substance resources, but no anticomplement peptides have been reported from scorpions. Here, we attempt to explore scorpion-derived anticomplement peptides by scanning a small and specific scorpion toxin ...
Xudong Luo +11 more
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Scorpion Venom peptide, AGAP inhibits TRPV1 and potentiates the analgesic effect of lidocaine [PDF]
Heliyon, 2021 Sylvanus Kampo, Jiachuan Yu
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Stinging Salvation: Harnessing Scorpion Venom Peptides for Revolutionary Pain Relief [PDF]
ToxinsPeptides from scorpion venom, mainly in species such as Olivierus martensii (formerly Olivierus martensii Karsch, often designated BMK) (BmK) and Tityus serrulatus from the Buthidae family, show real promise as painkillers that skip opioids altogether ...
Reza Mosaddeghi-Heris +6 more
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Peptidomics and pharmacological profiling of Odontobuthus doriae (Buthidae) scorpion venom at the kappa opioid receptor [PDF]
Scientific ReportsScorpion venoms are rich in bioactive peptides, many of which act on ion channels and neurotransmitter systems, yet their capacity to interact with G protein-coupled receptors (GPCRs) has been largely unexplored.
Adel Abdollahnia +6 more
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