Kv1.3 palmitoylation regulates spatial distribution and channel removal from the immunological synapse [PDF]
Cellular and Molecular Life SciencesKv1.3 is the main voltage-gated potassium channel in T cells. At the immunological synapse (IS), it sustains Ca2⁺ signaling and facilitates T cell activation.
María Navarro-Pérez +5 more
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A novel mitochondrial Kv1.3–caveolin axis controls cell survival and apoptosis [PDF]
eLife, 2021 The voltage-gated potassium channel Kv1.3 plays an apparent dual physiological role by participating in activation and proliferation of leukocytes as well as promoting apoptosis in several types of tumor cells.
Jesusa Capera +9 more
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KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology [PDF]
Scientific Reports, 2021 The voltage-dependent potassium channel Kv1.3 plays essential roles in the immune system, participating in leukocyte activation, proliferation and apoptosis.
Albert Vallejo-Gracia +12 more
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Adaptor-mediated interaction between Kv1.3 and Nedd4-2 E3 ubiquitin ligase [PDF]
Communications BiologyThe voltage-gated potassium channel Kv1.3 is crucial for immune responses. During proinflammatory stimulation, Kv1.3 is upregulated, enhancing Ca²⁺ signaling and leukocyte activation. To prevent prolonged lymphocyte activity, excess Kv1.3 must be removed
Irene Estadella +4 more
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Identification of Novel Kv1.3 Channel-Interacting Proteins Using Proximity Labelling in T-Cells [PDF]
Cellular Physiology and BiochemistryBackground/Aims: Potassium channels regulate membrane potential, calcium flux, cellular activation and effector functions of adaptive and innate immune cells.
Dilpreet Kour
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Kv1.3 as an upstream regulator of oxidative stress-mediated neuroinflammation following organic dust exposure in murine in vitro, ex vivo, and in vivo models [PDF]
Frontiers in ToxicologyIntroductionInhalation of organic dust from concentrated animal production operations induces inflammation in the brain and respiratory tract.
Nyzil Massey +10 more
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Redox Biology, 2020 The potassium channel Kv1.3, involved in several important pathologies, is the target of a family of psoralen-based drugs whose mechanism of action is not fully understood.
Mario Zoratti +2 more
exaly +3 more sources
T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers. [PDF]
PLoS ONE, 2017 Kv1.3 is a voltage-gated potassium channel expressed on T cells that plays an important role in T cell activation. Previous studies have shown that blocking Kv1.3 channels in human T cells during activation results in reduced calcium entry, cytokine ...
Wai-Ping Fung-Leung +9 more
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Frontiers in Cellular Neuroscience, 2021 Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. IL-17 level is significantly increased in inflammatory conditions of the CNS, including but not limited to post-stroke and multiple sclerosis.
Han Liu +7 more
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Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex
Cells, 2020 The voltage-gated potassium channel Kv1.3 plays a crucial role during the immune response. The channel forms oligomeric complexes by associating with several modulatory subunits. KCNE4, one of the five members of the KCNE family, binds to Kv1.3, altering
Laura Solé +8 more
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