The Mitochondrial Routing of the Kv1.3 Channel [PDF]
Frontiers in Oncology, 2022 Voltage-gated potassium channels control neuronal excitability and cardiac action potentials. In addition, these proteins are involved in a myriad of cellular processes.
Jesusa Capera +5 more
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N-Terminal Tagging with GFP Enhances Selectivity of Agitoxin 2 to Kv1.3-Channel Binding Site [PDF]
Toxins, 2020 Recently developed fluorescent protein-scorpion toxin chimeras (FP-Tx) show blocking activities for potassium voltage-gated channels of Kv1 family and retain almost fully pharmacological profiles of the parental peptide toxins (Kuzmenkov et al., Sci Rep.
Oksana V. Nekrasova +9 more
doaj +3 more sources
Voltage-Gated Potassium Channel Kv1.3 as a Target in Therapy of Cancer [PDF]
Frontiers in Oncology, 2019 Voltage-gated potassium channel Kv1.3 is an integral membrane protein, which is selectively permeable for potassium ions and is activated upon a change of membrane potential.
Andrzej Teisseyre +3 more
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Toxins, 2016 The Kv1.3 channel-acting scorpion toxins usually adopt the conserved anti-parallel β-sheet domain as the binding interface, but it remains challenging to discover some highly selective Kv1.3 channel-acting toxins.
Fang Ye +7 more
doaj +4 more sources
Combining mKate2-Kv1.3 Channel and Atto488-Hongotoxin for the Studies of Peptide Pore Blockers on Living Eukaryotic Cells [PDF]
Toxins, 2022 The voltage-gated potassium Kv1.3 channel is an essential component of vital cellular processes which is also involved in the pathogenesis of some autoimmune, neuroinflammatory and oncological diseases.
Nikita A. Orlov +6 more
doaj +2 more sources
Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis [PDF]
Frontiers in Pharmacology, 2021 Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation.
Ioannis Markakis +13 more
doaj +2 more sources
Atto488-Agitoxin 2—A Fluorescent Ligand with Increased Selectivity for Kv1.3 Channel Binding Site [PDF]
Bioengineering, 2022 Fluorescently labeled peptide blockers of ion channels are useful probes in studying the localization and functioning of the channels and in the performance of a search for new channel ligands with bioengineering screening systems. Here, we report on the
Kristina R. Denisova +5 more
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Recombinant Expression in Pichia pastoris System of Three Potent Kv1.3 Channel Blockers: Vm24, Anuroctoxin, and Ts6 [PDF]
Journal of Fungi, 2022 The Kv1.3 channel has become a therapeutic target for the treatment of various diseases. Several Kv1.3 channel blockers have been characterized from scorpion venom; however, extensive studies require amounts of toxin that cannot be readily obtained ...
Jesús Borrego +8 more
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Identification of Novel Kv1.3 Channel-Interacting Proteins Using Proximity Labelling in T-Cells [PDF]
Cellular Physiology and BiochemistryBackground/Aims: Potassium channels regulate membrane potential, calcium flux, cellular activation and effector functions of adaptive and innate immune cells.
Dilpreet Kour
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Kv1.3 Channel as a Key Therapeutic Target for Neuroinflammatory Diseases: State of the Art and Beyond [PDF]
Frontiers in Neuroscience, 2020 It remains a challenge for the effective treatment of neuroinflammatory disease, including multiple sclerosis (MS), stroke, epilepsy, and Alzheimer’s and Parkinson’s disease.
Xiaoli Wang +12 more
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