Cell Death and Disease, 2021 Cellular energy metabolism is fundamental for all biological functions. Cellular proliferation requires extensive metabolic reprogramming and has a high energy demand. The Kv1.3 voltage-gated potassium channel drives cellular proliferation.
Faye L. Styles +11 more
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Chlorpromazine directly inhibits Kv1.3 channels by facilitating the inactivation of channels
Molecular BrainKv1.3 channels in microglia are pivotal in regulating neuroinflammation. The antipsychotic chlorpromazine (CPZ) demonstrates anti-inflammatory effects by decreasing Kv1.3 activity in mPFC microglia.
Seo-In Park +7 more
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Co-Inhibition of Kv1.3 Channel Activity by Selected Chalcones and Statins in a Model of Cancer Cell Line Jurkat T [PDF]
MoleculesVoltage-gated potassium channel Kv1.3 plays an important role in the regulation of survival and apoptosis in many cell types, including both normal and cancer cells. Inhibitors of these channels may potentially find clinical applications in the treatment
Andrzej Teisseyre +4 more
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Eplerenone Reverses Cardiac Fibrosis via the Suppression of Tregs by Inhibition of Kv1.3 Channel [PDF]
Frontiers in Physiology, 2018 Background: Fibroblast proliferation is a critical feature during heart failure development. Previous studies reported regulatory T-lymphocytes (Tregs)’ protective role against myocardial fibrosis. However, notably, Tregs also secrete fibrogenic cytokine
Pei-Pei Shao +7 more
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Temporal profiling of Kv1.3 channel expression in brain mononuclear phagocytes following ischemic stroke [PDF]
Journal of Neuroinflammation, 2019 Background Microglia and CNS-infiltrating monocytes/macrophages (CNS-MPs) perform pro-inflammatory and protective anti-inflammatory functions following ischemic stroke.
Tianwen Gao +8 more
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GFP-Margatoxin, a Genetically Encoded Fluorescent Ligand to Probe Affinity of Kv1.3 Channel Blockers. [PDF]
Int J Mol Sci, 2022 Peptide pore blockers and their fluorescent derivatives are useful molecular probes to study the structure and functions of the voltage-gated potassium Kv1.3 channel, which is considered as a pharmacological target in the treatment of autoimmune and ...
Denisova KR +7 more
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Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis [PDF]
Cell & Bioscience, 2017 Background Disruption of blood–brain barrier (BBB) and subsequent infiltration of auto-reactive T lymphocytes are major characteristics of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).
Jie Huang +10 more
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Mitochondrial ultrastructure and glucose signaling pathways attributed to the Kv1.3 ion channel [PDF]
Frontiers in Physiology, 2016 Gene-targeted deletion of the potassium channel Kv1.3 (Kv1.3-/-) results in ‘Super-smeller’ mice with a sensory phenotype that includes an increased olfactory ability linked to changes in olfactory circuitry, increased abundance of olfactory cilia, and ...
Christopher P. Kovach +5 more
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Toxins Targeting the KV1.3 Channel: Potential Immunomodulators for Autoimmune Diseases
Toxins, 2015 Autoimmune diseases are usually accompanied by tissue injury caused by autoantigen-specific T-cells. KV1.3 channels participate in modulating calcium signaling to induce T-cell proliferation, immune activation and cytokine production.
Yipeng Zhao +6 more
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Adaptor-mediated interaction between Kv1.3 and Nedd4-2 E3 ubiquitin ligase [PDF]
Communications BiologyThe voltage-gated potassium channel Kv1.3 is crucial for immune responses. During proinflammatory stimulation, Kv1.3 is upregulated, enhancing Ca²⁺ signaling and leukocyte activation. To prevent prolonged lymphocyte activity, excess Kv1.3 must be removed
Irene Estadella +4 more
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