Kv1.3 palmitoylation regulates spatial distribution and channel removal from the immunological synapse [PDF]
Cellular and Molecular Life SciencesKv1.3 is the main voltage-gated potassium channel in T cells. At the immunological synapse (IS), it sustains Ca2⁺ signaling and facilitates T cell activation.
María Navarro-Pérez +5 more
doaj +3 more sources
Genistein and Resveratrol: Inhibitors of Kv1.3 Channels in Cancer Cells [PDF]
MembranesBackground: Genistein and resveratrol are bioactive compounds isolated from plants, recognized for their diverse biological activities including anti-cancer properties.
Andrzej Teisseyre +3 more
doaj +4 more sources
Tyrosine phosphorylation of the Kv1.3 potassium channel [PDF]
The Journal of Neuroscience, 1996 Kv1.3, a voltage-dependent potassium channel cloned from mammalian brain and T lymphocytes, contains multiple tyrosine residues that are putative targets for tyrosine kinases.
IB Levitan, TC Holmes, DA Fadool
core +3 more sources
A novel mitochondrial Kv1.3–caveolin axis controls cell survival and apoptosis [PDF]
eLife, 2021 The voltage-gated potassium channel Kv1.3 plays an apparent dual physiological role by participating in activation and proliferation of leukocytes as well as promoting apoptosis in several types of tumor cells.
Jesusa Capera +9 more
doaj +2 more sources
Nanobody regulation of C-type inactivation in Kv1.3 channels [PDF]
Nature CommunicationsNanobodies are powerful tools for modulating ion channels for mechanistic investigations and developing new therapeutics. The Kv1.3 channel is highly expressed in T-lymphocytes where it promotes sustained T-cell activation, its expression is elevated in ...
Purushotham Selvakumar +2 more
doaj +4 more sources
Binding Modes of Two Scorpion Toxins to the Voltage-Gated Potassium Channel Kv1.3 Revealed from Molecular Dynamics [PDF]
Toxins, 2014 Molecular dynamics (MD) simulations are used to examine the binding modes of two scorpion toxins, margatoxin (MgTx) and hongotoxin (HgTx), to the voltage gated K+ channel, Kv1.3. Using steered MD simulations, we insert either Lys28 or Lys35 of the toxins
Rong Chen, Shin-Ho Chung
doaj +2 more sources
PLoS ONE, 2014 Kv1.3 channel is a delayed rectifier channel abundant in human T lymphocytes. Chronic inflammatory and autoimmune disorders lead to the over-expression of Kv1.3 in T cells.
Panpan Hou +6 more
doaj +2 more sources
Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex [PDF]
Cells, 2020 The voltage-gated potassium channel Kv1.3 plays a crucial role during the immune response. The channel forms oligomeric complexes by associating with several modulatory subunits. KCNE4, one of the five members of the KCNE family, binds to Kv1.3, altering
Laura Solé +8 more
doaj +4 more sources
KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology [PDF]
Scientific Reports, 2021 The voltage-dependent potassium channel Kv1.3 plays essential roles in the immune system, participating in leukocyte activation, proliferation and apoptosis.
Albert Vallejo-Gracia +12 more
doaj +2 more sources
Characterization of endogenous Kv1.3 channel isoforms in T cells [PDF]
Journal of Cellular Physiology, 2023 Producción CientíficaVoltage-dependent potassium channel Kv1.3 plays a key role on T-cell activation; however, lack of reliable antibodies has prevented its accurate detection under endogenous circumstances.
Peraza, Diego A. +30 more
core +4 more sources